Synthesis, Configurational Assignment and Conformational Analysis of β-Hydroxy Sulfoxides, Bioisosteres of Oxisuran Metabolites, and their O-Methyl Derivatives was written by Alvarez-Ibarra, C.;Cuervo-Rodriguez, R.;Fernandez-Monreal, M. C.;Ruiz, M. P.. And the article was included in Journal of Organic Chemistry in 1994.Synthetic Route of C7H8N2O2 This article mentions the following:
Synthesis, configurational assignment, and conformational anal. of diastereoisomers of 2-(methylsulfinyl)-1-(2-quinolyl)ethanol, 2-(methylsulfinyl)-1-(1-isoquinolyl)ethanol, 2-(methylsulfinyl)-1-(2-pyrazinyl)ethanol, and their O-Me derivatives are reported. The configurational assignment and conformational anal. of the two diastereoisomers of β-hydroxy sulfoxides and β-methoxy sulfoxides have been carried out from the observed vicinal coupling constants using the mol. mechanics force field (MMX) and the Altona relationship as fundamental tools. The conformational equilibrium is explained in terms of polar and steric factors. Of significant importance was the role of intramol. hydrogen bonding in the RS/SR isomers of β-hydroxy sulfoxides. In the experiment, the researchers used many compounds, for example, Ethyl pyrazine-2-carboxylate (cas: 6924-68-1Synthetic Route of C7H8N2O2).
Ethyl pyrazine-2-carboxylate (cas: 6924-68-1) belongs to pyrazine derivatives. Pyrazine has the elements of symmetry for the point group D2h. It has three mutually perpendicular two-fold axes. It also has three mutually perpendicular planes of symmetry. As a result, pyrazine also has a centre of symmetry. Pyrazines undergo nearly all of the same reactions as pyrimidines, from nucleophilic substitution (SNAr) to palladium-catalyzed cross coupling reactions.Synthetic Route of C7H8N2O2