Synthesis and biological evaluation of pyrido[2,3-b]pyrazine and pyrido[2,3-b]pyrazine-N-oxide as selective glycine antagonists was written by Cugola, Alfredo;Donati, Daniele;Guarneri, M.;Micheli, Fabrizio;Missio, Andrea;Pecunioso, Angelo;Reggiani, Angelo;Tarzia, G.;Zanirato, V.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 1996.Synthetic Route of C7H5N3 This article mentions the following:
Pyrido[2,3-b]pyrazines and pyrido[2,3-b]pyrazines-N-oxides have been synthesized and evaluated for in vitro/in vivo antagonistic activity at the glycine site on the NMDA receptor. Efforts to improve the glycine vs. AMPA selectivity focussed on both aromatic substitution and on modification of the heterocyclic ring. The compounds showed a good affinity for the glycine binding site and > 100-fold selectivity vs. the AMPA receptor. In the experiment, the researchers used many compounds, for example, Pyrido[2,3-b]pyrazine (cas: 322-46-3Synthetic Route of C7H5N3).
Pyrido[2,3-b]pyrazine (cas: 322-46-3) belongs to pyrazine derivatives. Pyrazine is an N-heterocyclic moiety, and it can be easily prepared from ethylenediamine and 1,2-diketone, α-hydroxyketone, α-methyl ketone. Pyrazines undergo nearly all of the same reactions as pyrimidines, from nucleophilic substitution (SNAr) to palladium-catalyzed cross coupling reactions.Synthetic Route of C7H5N3