Alkylating reduction of some polynitrogen heteroaromatic compounds was written by Cosmao, Jean Marie;Collignon, Noel;Queguiner, Guy. And the article was included in Journal of Heterocyclic Chemistry in 1979.Electric Literature of C7H5N3 This article mentions the following:
The reduction-alkylation of quinoxaline, phthalazine and pyrido[2,3-b]pyrazine by KBH4 in a carboxylic acid medium is described. HCO2H, HOAc, ClCH2CO2H, and EtCO2H were used. The diazine ring of the mol. was reduced and alkylated into an N,N‘-dialkyltetrahydro compound With quinoxaline and HCO2H, N-formylation may be an important factor. Sodium borodeuteride gave a hexadeuterated compound In the experiment, the researchers used many compounds, for example, Pyrido[2,3-b]pyrazine (cas: 322-46-3Electric Literature of C7H5N3).
Pyrido[2,3-b]pyrazine (cas: 322-46-3) belongs to pyrazine derivatives. Pyrazine is a symmetrical molecule with point group D2h. Pyrazine is less basic than pyridine, pyridazine and pyrimidine. Pyrazines are chemical compounds (technically called “methoxypyrazines”) found in grape skin and stems that are responsible for many “green” flavors in wine. Levels of pyrazines are dependent on viticultural practices, climate, and grape variety.Electric Literature of C7H5N3