Design, synthesis, and biological evaluation of novel tetramethylpyrazine derivatives as potential neuroprotective agents was written by Chen, Haiyun;Tan, Guolian;Cao, Jie;Zhang, Gaoxiao;Yi, Peng;Yu, Pei;Sun, Yewei;Zhang, Zaijun;Wang, Yuqiang. And the article was included in Chemical & Pharmaceutical Bulletin in 2017.Recommanded Product: 75907-74-3 This article mentions the following:
A series of tetramethylpyrazine (TMP) derivatives, e.g., I were designed, synthesized and investigated their abilities for scavenging free radicals and preventing against oxidative stress-induced neuronal damage in vitro. Among them, compound, I consisting of TMP, caffeic acid and a nitrone group, showed potent radical-scavenging activity. Compound, I had broad neuroprotective effects, including rescuing iodoacetic acid-induced neuronal loss and, preventing from tert-butylhydroperoxide (t-BHP)-induced neuronal injury. Compound, I exerted its neuroprotective effect against t-BHP injury via activation of the phosphatidyl inositol 3-kinase (P13K)/Akt signaling pathway. Furthermore, in a rat model of permanent middle cerebral artery occlusion, compound, e.g., I significantly improved neurol. deficits, and alleviated the infarct area and brain edema. Thus, the results suggest that compound I could be a potential neuroprotective agent for the treatment of neurol. disease, particularly ischemic stroke. In the experiment, the researchers used many compounds, for example, (3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3Recommanded Product: 75907-74-3).
(3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3) belongs to pyrazine derivatives. Pyrazines are part of several biologically active polycyclic compounds; examples are quinoxalines, phenazines; and the bio-luminescent natural products pteridines, flavins, and their derivatives. Pyrazine and a variety of alkylpyrazines are flavor and aroma compounds found in baked and roasted goods. Tetramethylpyrazine (also known as ligustrazine) is reported to scavenge superoxide anion and decrease nitric oxide production in human Granulocytes.Recommanded Product: 75907-74-3