Discovery of a new tetramethylpyrazine based chalcone with α, β-Unsaturated ketone moiety as a potential anticancer agent was written by Bukhari, Syed Nasir Abbas. And the article was included in International Journal of Research in Pharmaceutical Sciences (Madurai, India) in 2020.Related Products of 75907-74-3 This article mentions the following:
In this study, a new ligustrazine-based chalcone mol. has been synthesized that contains an extra alpha, beta-Unsaturated ketone moiety along with alpha, the beta-Unsaturated carbonyl group of chalone. A new tetramethylpyrazine (TMP) based aldehyde was synthesized to make the TMP (ligustrazine) as part of chalcone and then it was reacted with newly synthesized ketone containing addnl. alpha, beta-Unsaturated ketone moiety. After characterization, this new compound was evaluated for its effect on different types of cancer cell lines and very promising results were obtained. The growth of these cancer cells was inhibited by newly designed and synthesized compounds, especially for colon and pancreatic cancer cells with IC50 0.04 – 0.05 μM. In the experiment, the researchers used many compounds, for example, (3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3Related Products of 75907-74-3).
(3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3) belongs to pyrazine derivatives. Pyrazine has the elements of symmetry for the point group D2h. It has three mutually perpendicular two-fold axes. It also has three mutually perpendicular planes of symmetry. As a result, pyrazine also has a centre of symmetry. A number of pyrazine-based derivatives were used as dyes or fluorescent probes.Related Products of 75907-74-3