The reaction of alkylpyrazine anions with some electrophiles. Synthesis of 1,2-bis(2-pyrazyl)ethanes was written by Houminer, Yoram;Sanders, Edward B.. And the article was included in Journal of Heterocyclic Chemistry in 1980.Computed Properties of C8H12N2O This article mentions the following:
The coupling of pyrazines I (R-R2 = Me, H; R = R1 = H, R2 = Me; R = Me, R1 = R2 = H) using LiN(CHMe)2(LDA)-iodine gave II (31-43%). The treatment of I (R-R2 = Me) with LDA and O gave 21% I (R = CH2OH, R1 = R2 = Me), which was coupled with I (R = Me, R1 = R2 = H) to yield 49% III. (±)- And meso–IV were prepared by the treatment of 5,6,7,8-tetrahydroquinoxaline with LDA and O. In the experiment, the researchers used many compounds, for example, (3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3Computed Properties of C8H12N2O).
(3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3) belongs to pyrazine derivatives. Pyrazine has the elements of symmetry for the point group D2h. It has three mutually perpendicular two-fold axes. It also has three mutually perpendicular planes of symmetry. As a result, pyrazine also has a centre of symmetry. Pyrazines undergo nearly all of the same reactions as pyrimidines, from nucleophilic substitution (SNAr) to palladium-catalyzed cross coupling reactions.Computed Properties of C8H12N2O