Regioselectivity in the catalytic hydrogenation of some pyrido[2,3-b]pyrazines was written by Cosmao, Jean Marie;Collignon, Noel;Queguiner, Guy. And the article was included in Canadian Journal of Chemistry in 1982.Category: pyrazines This article mentions the following:
Catalytic hydrogenation of pyridopyrazines I (R = H, R1 = Me, Ph; R = R1 = Me) on Pd-C in EtOH gave mixtures of the 1,2,3,4- and 5,6,7,8-tetrahydro derivatives Similar reduction of I (R = R1 = H) takes place on the pyrazine ring and, in the case of I (R = R1 = Ph) (II) the pyridine ring is reduced. In pure AcOH this reduction provides only 1,2,3,4-tetrahydropyrido[2,3-b]pyrazines. A study of the reduction of II and several di- and tetrahydro derivatives as a function of solvent acidity suggests that the observed selectivity could result from the isomerization of partially hydrogenated intermediates. In the experiment, the researchers used many compounds, for example, Pyrido[2,3-b]pyrazine (cas: 322-46-3Category: pyrazines).
Pyrido[2,3-b]pyrazine (cas: 322-46-3) belongs to pyrazine derivatives. Pyrazines are volatile compounds that are used in the cosmetic, food, flavor, and fragrance industries. Substituted pyrazines have been found as subunits of multiple synthetically constructed therapeutic agents, as well as several natural products.Category: pyrazines