Month: January 2023

Study of the reaction of organomagnesium compounds with pyrido[2,3-b]pyrazines was written by Vinot, Nicole;Maitte, Pierre. And the article was included in Bulletin de la Societe Chimique de France in 1976.Computed Properties of C7H5N3 This article mentions the following:

Pyridopyrazines I (R = H, Br, R1 = R2 = H) reacted with organomagnesium halides to give tetrahydropyridopyrazines II (R = H, Br, R3 = Me, Et, vinyl, Ph). I (R = H, Br, R1 = R2 = Ph) similarly gave III (R3 = Me, Et), I (R = R2 = H, R1 = Ph) gave IV (R3 = Me, Ph), and I (R = Br, R1 = Ph, R2 = H) gave V. In the experiment, the researchers used many compounds, for example, Pyrido[2,3-b]pyrazine (cas: 322-46-3Computed Properties of C7H5N3).

Pyrido[2,3-b]pyrazine (cas: 322-46-3) belongs to pyrazine derivatives. Pyrazinesare six-membered aromatic heterocyclic organic compounds with two nitrogen atoms at 1,4-positions. Pyrazine is a weaker base (pKb = 13.4) than pyridine (pKb = 8.8), pyrimidine (pKb = 12.7). Pyrazines undergo nearly all of the same reactions as pyrimidines, from nucleophilic substitution (SNAr) to palladium-catalyzed cross coupling reactions.Computed Properties of C7H5N3

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Discovery of tetrasubstituted pyrazines as semiochemicals in a sexually deceptive orchid was written by Bohman, Bjorn;Jeffares, Lynne;Flematti, Gavin;Byrne, Lindsay T.;Skelton, Brian W.;Phillips, Ryan D.;Dixon, Kingsley W.;Peakall, Rod;Barrow, Russell A.. And the article was included in Journal of Natural Products in 2012.HPLC of Formula: 75907-74-3 This article mentions the following:

Sexually deceptive orchids employ mimicry of insect sex pheromones to exploit a diverse group of pollinators. The chem. structures of five semiochems. (1-3, 7, 8) produced by populations of the warty hammer orchid, Drakaea livida, pollinated by a thynnine wasp in the genus Catocheilus were elucidated. With the exception of (2,5-dimethylpyrazin-3-yl)methyl 3-methylbutanoate (7), all active compounds were tetrasubstituted pyrazines, including hydroxymethyl (1) and ester (2 and 3) trimethylpyrazine derivatives Male Catocheilus wasps were responsive to all of these compounds in GC-EAD experiments In the experiment, the researchers used many compounds, for example, (3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3HPLC of Formula: 75907-74-3).

(3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3) belongs to pyrazine derivatives. Pyrazine heterocycles and their benzo derivatives possess many interesting properties, including chemical reactivity profiles, and have diverse applications in total synthesis, medicine, chemical biology, materials, dyes, and imaging. Pyrazines undergo nearly all of the same reactions as pyrimidines, from nucleophilic substitution (SNAr) to palladium-catalyzed cross coupling reactions.HPLC of Formula: 75907-74-3

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Infrared study of hydrogen bonds involving N-heterocyclic bases and phenols was written by Goethals, Muriel;Czarnik-Matusewicz, Boguslawa;Zeegers-Huyskens, Therese. And the article was included in Journal of Heterocyclic Chemistry in 1999.Formula: C7H5N3 This article mentions the following:

The hydrogen bond complexes between phenols and N-heteroaromatic bases 2,4,6-tri(2-pyridyl)-1,3,5-triazine, 2,2′,2″-terpyridine, quinoxaline, pyrido[2,3-b]pyrazine, pyzazino[2,3-f]quinoxaline and 5-nitrophenanthroline are investigated by IR spectroscopy in 1,2-dichloroethane. The stability constants of the complexes involving N-heteroaromatic bases characterized by two vicinal nitrogen atoms having lone pairs pointing to each other are higher than predicted from their basicity. Possible differences between protonation and hydrogen bond formation are discussed. N-heteroaromatic bases such as tri(2-pyridyl)-1,3,5-triazine or phenanthrolines cannot be considered as proton sponges but their behavior is intermediate between that of the classical heteroaromatic bases and the proton sponges. In the experiment, the researchers used many compounds, for example, Pyrido[2,3-b]pyrazine (cas: 322-46-3Formula: C7H5N3).

Pyrido[2,3-b]pyrazine (cas: 322-46-3) belongs to pyrazine derivatives. Pyrazinesare six-membered aromatic heterocyclic organic compounds with two nitrogen atoms at 1,4-positions. Pyrazine is a weaker base (pKb = 13.4) than pyridine (pKb = 8.8), pyrimidine (pKb = 12.7). Pyrazine heterocycles and their benzo derivatives possess many interesting properties, including chemical reactivity profiles, and have diverse applications in total synthesis, medicine, chemical biology, materials, dyes, and imaging.Formula: C7H5N3

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Pyrido[2,3-b]- and -[3,4-b]pyrazines was written by Boutte, Daniel;Queguiner, Guy;Pastour, Paul. And the article was included in Comptes Rendus des Seances de l’Academie des Sciences, Serie C: Sciences Chimiques in 1971.Name: Pyrido[2,3-b]pyrazine This article mentions the following:

Reduction, oxidation, and treatment by organometallic reagents and alkyl iodides of pyrido[2,3-b]- (I) and pyrido[3,4-b]pyrazine (II) are reported. Reduction of I and II with LiAlH4 gives the resp. 1,2,3,4-tetrahydro derivatives (III and IV). Reaction of III with 1 and 2 moles BzCl gives the 1-benzoyl and 1,4-dibenzoyl derivatives, resp. IV gives only a 1,4-dibenzoyl derivative Oxidn of II by KMnO4 at 100° gives, after esterification with EtOH, di-Et 2,3-pyrazine-dicarboxylate. Under similar conditions, the 2,3-di-Me derivative (V) of II gives di-Et 5,6-dimethyl-2,3-pyrazinedicarboxylate. Reaction of I with MeMgI in Et2O at 25° gives only the 2,3-di-Me2 derivative (IV) of III. II similarly gives the 2,3-di-Me derivative (VII) of IV. EtMgI with I in THF gives 20% 6-ethyl-5,6-dihydropyrido[2,3-b]pyrazine. With KMnO4 in Me2CO, VI gives the 2,3-di-Me derivative of I, but VII in air spontaneously gives V. Reaction of II with 4-O2NC6H4CO2O in Et2O gives the 6-oxide. No N-oxide from I was isolable. Oxidation of I with the 3 peracids gives only IX-X, (IX predominating). In the experiment, the researchers used many compounds, for example, Pyrido[2,3-b]pyrazine (cas: 322-46-3Name: Pyrido[2,3-b]pyrazine).

Pyrido[2,3-b]pyrazine (cas: 322-46-3) belongs to pyrazine derivatives. Pyrazine derivatives have antitumor, antibiotic, anticonvulsant, antituberculous and diuretic effects as well as kinase, enzymatic and potent tubulin and FtsZ polymerization inhibitory activities. Pyrazines undergo nearly all of the same reactions as pyrimidines, from nucleophilic substitution (SNAr) to palladium-catalyzed cross coupling reactions.Name: Pyrido[2,3-b]pyrazine

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Pyrazine derivatives. VIII. Preparation of some amino pyrazines by the Curtius reaction was written by Schut, W. J.;Mager, H. I. X.;Barends, W.. And the article was included in Recueil des Travaux Chimiques des Pays-Bas in 1963.Related Products of 89323-09-1 This article mentions the following:

2 – (N – Benzyloxycarbonylamino) – 5 – ethoxycarbonylpyrazine (I) (6.025 g.) and 150 ml. 4N HCl refluxed 3 hrs., evaporated to dryness in vacuo, 10 ml. H₂O added, the pH adjusted to 3, and the precipitate filtered off gave 2.1 g. 2-aminopyrazine-5-carboxylic acid (II), m. 283° (decomposition) (evacuated tube in bath preheated to 260°) (H₂O). To a hydrogenated mixture of 95 mg.% Pd-C and 20 mg. 3% aqueous NaOH was added 0.9563 g. I and the whole hydrogenated at room temperature and atm. press., 90 ml. H₂O added, the mixture filtered, the filtrate concentrated in vacuo to 10 ml., the pH adjusted to 3, and the solid filtered off gave 0.445 g. II. Hydrogenation of 1.2052 g. I, 120 mg. 10% Pd-C, and 30 ml. 96% EtOH gave 0.656 g. 2-amino-5-ethoxycarbonylpyrazine, m. 174-5°. Similarly, 2-(N-benzyloxycarbonylamino)-5-carba-moylpyrazine (III) gave 87% 2-amino-5-carbamoylpyrazine, m. 274-6°. I (2g.) in 75 ml. EtOH saturated at 0° with NH₃ and the whole kept 4 days at -5° gave 1.57 g. III. In the experiment, the researchers used many compounds, for example, 5-Aminopyrazine-2-carboxamide (cas: 89323-09-1Related Products of 89323-09-1).

5-Aminopyrazine-2-carboxamide (cas: 89323-09-1) belongs to pyrazine derivatives. Pyrazine heterocycles and their benzo derivatives possess many interesting properties, including chemical reactivity profiles, and have diverse applications in total synthesis, medicine, chemical biology, materials, dyes, and imaging. A large number of pyrazine derivatives are known for their antitumor, antibiotic, anticonvulsant, antituberculosis, and diuretic activities.Related Products of 89323-09-1

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Pyridazine analogs of biologically active compounds. Part III. Synthetic investigations directed to azanicotines and congeners was written by Heinisch, Gottfried;Jentzsch, Alexander;Kirchner, Ingrid;Loetsch, Gerhard. And the article was included in Vestnik Slovenskega Kemijskega Drustva in 1986.Electric Literature of C7H8N2O2 This article mentions the following:

Synthetic approaches providing access to novel analogs of nicotine, e.g., I (R = Me) and nornicotine, e.g., I (R = H) are investigated. Homolytic α-N-amidoalkylation permits C-C bond formation between pyridazine (C-4), pyrimidine (C-4), pyrazine (C-2) or quinoline (C-4) and N-formyl- or N-acetyl-pyrrolidine. The N-formylnornicotinoids are converted into 1-methyl-2-heteroarylpyrrolidines by reduction Hydrolysis of the corresponding N-acetyl derivatives affords aza-nor-nicotines and related compounds In the experiment, the researchers used many compounds, for example, Ethyl pyrazine-2-carboxylate (cas: 6924-68-1Electric Literature of C7H8N2O2).

Ethyl pyrazine-2-carboxylate (cas: 6924-68-1) belongs to pyrazine derivatives. Pyrazines are part of several biologically active polycyclic compounds; examples are quinoxalines, phenazines; and the bio-luminescent natural products pteridines, flavins, and their derivatives. Pyrazine and a variety of alkylpyrazines are flavor and aroma compounds found in baked and roasted goods. Tetramethylpyrazine (also known as ligustrazine) is reported to scavenge superoxide anion and decrease nitric oxide production in human Granulocytes.Electric Literature of C7H8N2O2

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Quantum-chemical description of the basicity of azanaphthalenes was written by Zarqua, Tamar;Kereselidze, Jumber;Pachulia, Zurab. And the article was included in Sakartvelos Mecnierebata Akademiis Macne, Kimiis Seria in 2008.Recommanded Product: 322-46-3 This article mentions the following:

Energetic and electronic characteristics of azanaphalenes have been calculated by means of semiempirical quantum-chem. AM1 method. It is shown that basicity of azanaphalenes linearly depends on enthalpy and sum of charge of nitrogen atoms, and the dependence on ionization potential is second order. In the experiment, the researchers used many compounds, for example, Pyrido[2,3-b]pyrazine (cas: 322-46-3Recommanded Product: 322-46-3).

Pyrido[2,3-b]pyrazine (cas: 322-46-3) belongs to pyrazine derivatives. Pyrazine is a symmetrical molecule with point group D2h. Pyrazine is less basic than pyridine, pyridazine and pyrimidine. Pyrazine heterocycles and their benzo derivatives possess many interesting properties, including chemical reactivity profiles, and have diverse applications in total synthesis, medicine, chemical biology, materials, dyes, and imaging.Recommanded Product: 322-46-3

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Spin polarization conservation during triplet-triplet energy transfer in fluid solution as studied by time-resolved ESR spectroscopy was written by Akiyama, Kimio;Kaneko, Atsuko;Tero-Kubota, Shozo;Ikegami, Yusaku. And the article was included in Journal of the American Chemical Society in 1990.Related Products of 322-46-3 This article mentions the following:

Electron polarization of pyridinyl radicals generated from the photosensitized dissociation of the dimers was studied. Addition of triplet sensitizer to the dimer solution induced drastic change in the CIDEP spectrum. Examinations of the dependence of spectral change on the T₁ state energy level and the spin alignment in the T₁ sublevels of sensitizers lead to the conclusion that energy transfer between the pyridinyl dimer and the sensitizer occurred and that the spin polarization was conserved during the process. From a series of triplet donors, nonphosphorescent T₁ states of two types of pyridinyl dimers were estimated to be 2.43 eV for the 2,2′-dimer of 1-methyl-4-tert-butylpyridinyl and 2.65 eV for the 4,4′-dimer of 1-methylpyridinyl. In the experiment, the researchers used many compounds, for example, Pyrido[2,3-b]pyrazine (cas: 322-46-3Related Products of 322-46-3).

Pyrido[2,3-b]pyrazine (cas: 322-46-3) belongs to pyrazine derivatives. Pyrazine heterocycles and their benzo derivatives possess many interesting properties, including chemical reactivity profiles, and have diverse applications in total synthesis, medicine, chemical biology, materials, dyes, and imaging. Pyrazine heterocycles and their benzo derivatives possess many interesting properties, including chemical reactivity profiles, and have diverse applications in total synthesis, medicine, chemical biology, materials, dyes, and imaging.Related Products of 322-46-3

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Synthesis and Biological Evaluation of Ligustrazine Derivatives was written by Zhang, Chao;Chen, Lang-di;Liang, Xin-tong;Liu, Wei-xiong;Wu, Wen-hao. And the article was included in Chemistry of Natural Compounds in 2017.Formula: C8H12N2O This article mentions the following:

Synthesized ligustrazine derivatives (1a, 1b, 1c (novel)) were structurally confirmed by mass spectrometry, ¹H NMR, and ¹³C NMR. The cytotoxic activities of all derivatives were evaluated by MTS assay in three human prostate cancer cell lines (PC-3, LNCaP, and DU145) and in the A549 human lung cancer cell line. Compound 1a exhibited strong cytotoxic activity against PC-3 cells (IC₅₀ 3.63 μM). In addition, compounds 1-1c showed moderate α₁-adrenergic receptor (AR) subselective antagonistic and β₂-AR agonistic effects, indicating potential use for the treatment of chronic obstructive pulmonary disease. Mol. docking results showed 1b bound to one region of the active site in β₂-AR, but 1, 1a, and 1c bound to a different region. In the experiment, the researchers used many compounds, for example, (3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3Formula: C8H12N2O).

(3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3) belongs to pyrazine derivatives. Pyrazine has the elements of symmetry for the point group D2h. It has three mutually perpendicular two-fold axes. It also has three mutually perpendicular planes of symmetry. As a result, pyrazine also has a centre of symmetry. Pyrazine heterocycles and their benzo derivatives possess many interesting properties, including chemical reactivity profiles, and have diverse applications in total synthesis, medicine, chemical biology, materials, dyes, and imaging.Formula: C8H12N2O

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Synthesis of novel ligustrazine derivatives as potential platelet aggregation inhibitors was written by Cheng, Xian Chao;Liu, Xin Yong;Xu, Wen Fang. And the article was included in Chinese Chemical Letters in 2006.Related Products of 75907-74-3 This article mentions the following:

A series of novel ligustrazine derivatives were synthesized. These compounds have not been reported in literature, and their chem. structures were confirmed by IR, ¹H NMR and ESI-MS. The preliminary antiplatelet aggregation screening results demonstrated that the compounds 7a, 7b and 7c showed higher potency than ligustrazine. In the experiment, the researchers used many compounds, for example, (3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3Related Products of 75907-74-3).

(3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3) belongs to pyrazine derivatives. Pyrazine has the elements of symmetry for the point group D2h. It has three mutually perpendicular two-fold axes. It also has three mutually perpendicular planes of symmetry. As a result, pyrazine also has a centre of symmetry. Substituted pyrazines have been found as subunits of multiple synthetically constructed therapeutic agents, as well as several natural products.Related Products of 75907-74-3

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem