Modified synthesis of four kinds of azabicyclo compounds was written by Wang, Yu;Lu, Ming. And the article was included in Yingyong Huaxue in 2012.Related Products of 322-46-3 This article mentions the following:
Azabicyclo compounds of 1,4-benxodiazine, pyrido[2,3-b]pyrazine, 1H-benzimidazole, 3H-imidazo[4,5-b]pyridine were prepared from o-phenylenediamine or 2,3-diaminopyridine reacted with carbonyl compounds The effects of reaction medium, pH, time and other factors on the reactions were investigated. The results showed that the yield of pyrido[2,3-b]pyrazine could reach 89.4% when refluxed in propanol for 1 h at pH = 9 adjusted by methanol sodium. The yields for 1,4-benxodiazine could be increased to 98.3% in aqueous medium with pH = 9 adjusted by sodium sulfite at 60 °C after 40 min reaction. Here, the purification of target product could be achieved via a low temperature standing process instead of the vacuum distillation method. The optimized conditions for the other two compounds are: refluxing o-phenylenediamine for 2 h in 88% formic acid solution yielding 1H-benzimidazole with 92% yield; refluxing 2,3-diaminopyridine with triethoxy methane for 3 h followed by adding concentrated hydrochloric acid for another 1 h giving 3H-imidazo[4,5-b]pyridine with 84.2% yield. In the experiment, the researchers used many compounds, for example, Pyrido[2,3-b]pyrazine (cas: 322-46-3Related Products of 322-46-3).
Pyrido[2,3-b]pyrazine (cas: 322-46-3) belongs to pyrazine derivatives. Pyrazine heterocycles and their benzo derivatives possess many interesting properties, including chemical reactivity profiles, and have diverse applications in total synthesis, medicine, chemical biology, materials, dyes, and imaging. Pyrazine-based skeletons were incorporated into agents targeting a range of ailments. Many derivatives were synthesized and evaluated as potential cancer treatments.Related Products of 322-46-3