Study of the reaction of organomagnesium compounds with pyrido[2,3-b]pyrazines was written by Vinot, Nicole;Maitte, Pierre. And the article was included in Bulletin de la Societe Chimique de France in 1976.Computed Properties of C7H5N3 This article mentions the following:
Pyridopyrazines I (R = H, Br, R1 = R2 = H) reacted with organomagnesium halides to give tetrahydropyridopyrazines II (R = H, Br, R3 = Me, Et, vinyl, Ph). I (R = H, Br, R1 = R2 = Ph) similarly gave III (R3 = Me, Et), I (R = R2 = H, R1 = Ph) gave IV (R3 = Me, Ph), and I (R = Br, R1 = Ph, R2 = H) gave V. In the experiment, the researchers used many compounds, for example, Pyrido[2,3-b]pyrazine (cas: 322-46-3Computed Properties of C7H5N3).
Pyrido[2,3-b]pyrazine (cas: 322-46-3) belongs to pyrazine derivatives. Pyrazinesare six-membered aromatic heterocyclic organic compounds with two nitrogen atoms at 1,4-positions. Pyrazine is a weaker base (pKb = 13.4) than pyridine (pKb = 8.8), pyrimidine (pKb = 12.7). Pyrazines undergo nearly all of the same reactions as pyrimidines, from nucleophilic substitution (SNAr) to palladium-catalyzed cross coupling reactions.Computed Properties of C7H5N3