Pyrazine derivatives. VIII. Preparation of some amino pyrazines by the Curtius reaction was written by Schut, W. J.;Mager, H. I. X.;Barends, W.. And the article was included in Recueil des Travaux Chimiques des Pays-Bas in 1963.Related Products of 89323-09-1 This article mentions the following:
2 – (N – Benzyloxycarbonylamino) – 5 – ethoxycarbonylpyrazine (I) (6.025 g.) and 150 ml. 4N HCl refluxed 3 hrs., evaporated to dryness in vacuo, 10 ml. H2O added, the pH adjusted to 3, and the precipitate filtered off gave 2.1 g. 2-aminopyrazine-5-carboxylic acid (II), m. 283° (decomposition) (evacuated tube in bath preheated to 260°) (H2O). To a hydrogenated mixture of 95 mg.% Pd-C and 20 mg. 3% aqueous NaOH was added 0.9563 g. I and the whole hydrogenated at room temperature and atm. press., 90 ml. H2O added, the mixture filtered, the filtrate concentrated in vacuo to 10 ml., the pH adjusted to 3, and the solid filtered off gave 0.445 g. II. Hydrogenation of 1.2052 g. I, 120 mg. 10% Pd-C, and 30 ml. 96% EtOH gave 0.656 g. 2-amino-5-ethoxycarbonylpyrazine, m. 174-5°. Similarly, 2-(N-benzyloxycarbonylamino)-5-carba-moylpyrazine (III) gave 87% 2-amino-5-carbamoylpyrazine, m. 274-6°. I (2g.) in 75 ml. EtOH saturated at 0° with NH3 and the whole kept 4 days at -5° gave 1.57 g. III. In the experiment, the researchers used many compounds, for example, 5-Aminopyrazine-2-carboxamide (cas: 89323-09-1Related Products of 89323-09-1).
5-Aminopyrazine-2-carboxamide (cas: 89323-09-1) belongs to pyrazine derivatives. Pyrazine heterocycles and their benzo derivatives possess many interesting properties, including chemical reactivity profiles, and have diverse applications in total synthesis, medicine, chemical biology, materials, dyes, and imaging. A large number of pyrazine derivatives are known for their antitumor, antibiotic, anticonvulsant, antituberculosis, and diuretic activities.Related Products of 89323-09-1