Interactions of heterocyclic Maillard products with the hepatic microsomal monooxygenase system was written by Hahnemann, B.;Legrum, W.;Koss, G.;Netter, K. J.. And the article was included in Xenobiotica in 1989.Quality Control of (3,5,6-Trimethylpyrazin-2-yl)methanol This article mentions the following:
Interactions of methyl-substituted pyrazines, and other constituents of Maillard products generated during heat treatment of food, with hepatic microsomal mixed-function oxygenases were studied in vitro. Spectral interactions of N-containing heteroaromatic compounds with the cytochrome P 450 system are type I or type II depending on the state of induction, and are relatively weak. Inhibition of 7-ethoxycourmarin O-deethylation by these compounds is ten times lower than that of metyrapone, agreeing with the weak spectral interaction. Inhibition is competitive for 2,3-dimethylquinoxaline, and complex for 2,5-dimethylpyrazine and 2,3,5,6-tetramethylpyrazine. Spectral and inhibitory interactions indicate biotransformation. This was studied with 2,3,5,6-tetramethylpyrazine; the metabolite formed was 2-hydroxymethyl-3,5,6-trimethylpyrazine. Metabolism to the N-oxide did not occur. In the experiment, the researchers used many compounds, for example, (3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3Quality Control of (3,5,6-Trimethylpyrazin-2-yl)methanol).
(3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3) belongs to pyrazine derivatives. Pyrazine is a symmetrical molecule with point group D2h. Pyrazine is less basic than pyridine, pyridazine and pyrimidine. Pyrazines undergo nearly all of the same reactions as pyrimidines, from nucleophilic substitution (SNAr) to palladium-catalyzed cross coupling reactions.Quality Control of (3,5,6-Trimethylpyrazin-2-yl)methanol