6-Substituted amiloride derivatives as inhibitors of the urokinase-type plasminogen activator for use in metastatic disease was written by Buckley, Benjamin J.;Majed, Hiwa;Aboelela, Ashraf;Minaei, Elahe;Jiang, Longguang;Fildes, Karen;Cheung, Chen-Yi;Johnson, Darren;Bachovchin, Daniel;Cook, Gregory M.;Huang, Mingdong;Ranson, Marie;Kelso, Michael J.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2019.Recommanded Product: Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate This article mentions the following:
Aryldiaminopyrazinecarbonyl guanidines I (R = Ph, 4-MeSC6H4, 4-F3CC6H4, 5-pyrimidinyl, 2,4-dimethoxy-5-pyrimidinyl, 2-methoxy-5-pyrimidinyl, 2,6-dimethoxy-3-pyridinyl, 2-thienyl, 2-furanyl, 3-furanyl, 1-methyl-4-pyrazolyl, 2-benzothienyl, 5-R1-2-benzofuranyl, 6-methoxy-2-benzofuranyl, 2,3-dihydro-5-benzofuranyl; R1 = H, Me, MeO, F, Cl, Br, NC) were prepared as analogs of the potassium ion-sparing diuretic amiloride for the inhibition of urokinase-type plasminogen activator (uPA) and for inhibiting tumor metastasis. The structures of four aryldiaminopyrazinecarbonyl guanidines bound to uPA were determined by X-ray crystallog.; the improved inhibition of uPA by amiloride analogs likely arise from increased occupancy of uPA’s S1β subsite by the aryl substituents. I (R = 2-benzofuranyl, 2-methoxy-5-pyrimidinyl) were selective for uPA over related trypsin-like serine proteases and did not show diuretic or anti-kaliuretic effects in rats. I (R = 2-benzofuranyl) inhibited tumor metastasis in a murine xenograft lung cancer model. In the experiment, the researchers used many compounds, for example, Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate (cas: 1458-01-1Recommanded Product: Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate).
Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate (cas: 1458-01-1) belongs to pyrazine derivatives. Pyrazines are volatile compounds that are used in the cosmetic, food, flavor, and fragrance industries. Pyrazine and a variety of alkylpyrazines are flavor and aroma compounds found in baked and roasted goods. Tetramethylpyrazine (also known as ligustrazine) is reported to scavenge superoxide anion and decrease nitric oxide production in human Granulocytes.Recommanded Product: Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate