Novel transformation of 1,2,4-triazines into pyrazine derivatives was written by Alekseev, S. G.;Charushin, V. N.;Chupakhin, O. N.. And the article was included in Khimiya Geterotsiklicheskikh Soedinenii in 1987.Reference of 322-46-3 This article mentions the following:
Pyrazines I (X = e.g. CH, N) were prepared by the reaction of aromatic o-diamines with triazinium salt II and subsequent elimination of morpholinoamidrazone from the intermediate III. In the experiment, the researchers used many compounds, for example, Pyrido[2,3-b]pyrazine (cas: 322-46-3Reference of 322-46-3).
Pyrido[2,3-b]pyrazine (cas: 322-46-3) belongs to pyrazine derivatives. Pyrazine heterocycles and their benzo derivatives possess many interesting properties, including chemical reactivity profiles, and have diverse applications in total synthesis, medicine, chemical biology, materials, dyes, and imaging. Pyrazine and a variety of alkylpyrazines are flavor and aroma compounds found in baked and roasted goods. Tetramethylpyrazine (also known as ligustrazine) is reported to scavenge superoxide anion and decrease nitric oxide production in human Granulocytes.Reference of 322-46-3