2,3-Dihydroxy-1,4-dioxane: a stable synthetic equivalent of anhydrous glyoxal was written by Venuti, Michael C.. And the article was included in Synthesis in 1982.Reference of 322-46-3 This article mentions the following:
1,4-Dioxane-2,3-diol (I) was obtained in 45% yield by treating aqueous glyoxal with ethylene glycol. I reacts as glyoxal with diamines, aldehydes, alcs., and thio ethers to give, e.g., quinoxaline, isonaphthazarin, and 2,5-bis(4-bromobenzoyl)thiophene. In the experiment, the researchers used many compounds, for example, Pyrido[2,3-b]pyrazine (cas: 322-46-3Reference of 322-46-3).
Pyrido[2,3-b]pyrazine (cas: 322-46-3) belongs to pyrazine derivatives. Pyrazine is a symmetrical molecule with point group D2h. Pyrazine is less basic than pyridine, pyridazine and pyrimidine. Substituted pyrazines have been found as subunits of multiple synthetically constructed therapeutic agents, as well as several natural products.Reference of 322-46-3