Simple, fast and efficient synthesis of β-keto esters from the esters of heteroaryl compounds, its antimicrobial study and cytotoxicity towards various cancer cell lines was written by Venkat Ragavan, R.;Vijayakumar, V.;Rajesh, K.;Palakshi Reddy, B.;Karthikeyan, S.;Suchetha Kumari, N.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2012.Category: pyrazines This article mentions the following:
A series of β-keto esters were synthesized from heteroaryl esters and Et acetate using LiHMDS as base at -50 to -30 °C. Increases in yields of cross-condensed products were observed and the percentage of self-condensed product was reduced drastically by applying the suitable base (LiHMDS), solvent, and a min. amount of Et acetate. All these β-keto esters were characterized using 1H NMR, 13C NMR and mass spectral data. A plausible mechanism is also depicted to prove the formation of trans-esterified products. All the synthesized compounds were tested for their cytotoxicity towards various cancer cell lines and also tested for their antimicrobial activity towards various bacterial and fungal strains and some of them were found to have promising activity. In the experiment, the researchers used many compounds, for example, Ethyl pyrazine-2-carboxylate (cas: 6924-68-1Category: pyrazines).
Ethyl pyrazine-2-carboxylate (cas: 6924-68-1) belongs to pyrazine derivatives. Pyrazine is an N-heterocyclic moiety, and it can be easily prepared from ethylenediamine and 1,2-diketone, α-hydroxyketone, α-methyl ketone. Pyrazine-based skeletons were incorporated into agents targeting a range of ailments. Many derivatives were synthesized and evaluated as potential cancer treatments.Category: pyrazines