Protective effects of 2-hydroxymethyl-3,5,6-trimethylpyrazine on vascular endothelial cells injured by hydrogen peroxide was written by Li, Chaowu;Liu, Xinyong;Zhang, Rui;Xu, Wenfang;Li, Zhong;Wang, Defeng. And the article was included in Shandong Daxue Xuebao, Yixueban in 2003.Application In Synthesis of (3,5,6-Trimethylpyrazin-2-yl)methanol This article mentions the following:
The protective effects of 2-hydroxymethyl-3,5,6-trimethylpyrazine (HTMP) on human umbilical vein endothelial cells (HUVECs) injured by H2O2 were studied. HUVECs viability was assessed by Me thiazolyl tetrazolium assay and tetramethylpyrazine (TMP) was used as a controlled drug. HTMP (0.1-1.5 mM) highly stimulated the proliferation of normal HUVECs, and protected the injured HUVECs against suppression induced by H2O2, which had more potency than the pos. drug TMP. The exptl. data suggested that HTMP exerted protective action on injured HUVECs and had a great significance for repairing the injured endothelium in treatment of cardiovascular diseases. In the experiment, the researchers used many compounds, for example, (3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3Application In Synthesis of (3,5,6-Trimethylpyrazin-2-yl)methanol).
(3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3) belongs to pyrazine derivatives. Pyrazine heterocycles and their benzo derivatives possess many interesting properties, including chemical reactivity profiles, and have diverse applications in total synthesis, medicine, chemical biology, materials, dyes, and imaging. Pyrazine and a variety of alkylpyrazines are flavor and aroma compounds found in baked and roasted goods. Tetramethylpyrazine (also known as ligustrazine) is reported to scavenge superoxide anion and decrease nitric oxide production in human Granulocytes.Application In Synthesis of (3,5,6-Trimethylpyrazin-2-yl)methanol