Pyrazine diuretics. II. N-amidino-3-amino-5-substituted 6-halopyrazinecarboxamides was written by Cragoe, Edward J. Jr.;Woltersdorf, Otto W. Jr.;Bicking, John B.;Kwong, Sara F.;Jones, James Holden. And the article was included in Journal of Medicinal Chemistry in 1967.Computed Properties of C6H7ClN4O2 This article mentions the following:
The synthesis of a series of N-amidino-3-amino-5-substituted-6-halopyrazinecarboxamides (I) is described In rats and dogs, these compounds cause diuresis and saluresis while K excretion is unaffected or repressed Compounds with a variety of 5 substituents including hydroxy, alkoxy, mercapto, alkylmercapto, amino, and substitute amino were prepared The latter 2 tupes embrace compounds with the highest activity. Several routes for the synthesis of Me 3-amino-5,6-dichloropyrazinoate, a key intermediate, are presented. 23 references. In the experiment, the researchers used many compounds, for example, Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate (cas: 1458-01-1Computed Properties of C6H7ClN4O2).
Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate (cas: 1458-01-1) belongs to pyrazine derivatives. Pyrazine is a symmetrical molecule with point group D2h. Pyrazine is less basic than pyridine, pyridazine and pyrimidine. Pyrazine heterocycles and their benzo derivatives possess many interesting properties, including chemical reactivity profiles, and have diverse applications in total synthesis, medicine, chemical biology, materials, dyes, and imaging.Computed Properties of C6H7ClN4O2