Effects of 2-hydroxymethyl-3,5,6-trimethylpyrazine on cardiovascular system was written by Chen, Xue-Min;Cao, Yong-Xiao;Li, Guan-Wu;Lin, Zhang-Quan;Li, Xue-Fei;Liu, Jing. And the article was included in Zhongguo Yiyao Gongye Zazhi in 1998.Quality Control of (3,5,6-Trimethylpyrazin-2-yl)methanol This article mentions the following:
The cardiovascular effects of 2-hydroxymethyl-3,5,6-trimethylpyrazine (I), one of the major metabolites of tetramethylpyrazine, were studied. I significantly prolonged cardiac potential lasting time and blood coagulating time in mice. It also significantly deduced the arterial blood pressure but had no effect on heart rates in rats. It was demonstrated that I improved the anoxemia-resistant ability and had the effects of antihypertension and anticoagulation. In the experiment, the researchers used many compounds, for example, (3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3Quality Control of (3,5,6-Trimethylpyrazin-2-yl)methanol).
(3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3) belongs to pyrazine derivatives. Pyrazine has the elements of symmetry for the point group D2h. It has three mutually perpendicular two-fold axes. It also has three mutually perpendicular planes of symmetry. As a result, pyrazine also has a centre of symmetry. Pyrazines are chemical compounds (technically called “methoxypyrazines”) found in grape skin and stems that are responsible for many “green” flavors in wine. Levels of pyrazines are dependent on viticultural practices, climate, and grape variety.Quality Control of (3,5,6-Trimethylpyrazin-2-yl)methanol