Synthesis of compounds of pyridopyrazinedione/imidazole was written by Xia, Yong-gen;Lu, Ming. And the article was included in Jingxi Huagong Zhongjianti in 2014.Electric Literature of C7H5N3 This article mentions the following:
Several pyridopyrazinedione, pyridinoimidazole and pyridodiimidazole compounds were synthesized from 2,3-diaminopyridine and 2,3,5,6-tetraaminopyridine hydrochloride, and the reaction conditions were investigated. NH4Cl-CH3OH system has significant catalytic effects on synthesis of 2,3-dimethypyrido[2,3-b]pyrazine and 2,3-diethypyrido[2,3-b]pyrazine. Replacement of glyoxal with 4,5-dihydroxy-imidazolidin-2-one increased the product yield by its reaction with 2,3-diaminopyridine. Phosphomolybdic acid was a preferred catalyst for the preparation of pyridinoimidazole and 2-Me pyridinoimidazole. Likewise, 2,3,5,6-tetraaminopyridine hydrochloride was reacted with tri-Et orthoformate and tri-Me orthoacetate under catalysis of phosphomolybdic acid gave 2,6-dihydro-pyrido[2,3-b:5,6-b’]diimidazole and 2,6-dimethy-pyrido [2,3-b:5,6-b’]diimidazole in yield of 68.7% and 66.5%, resp. In the experiment, the researchers used many compounds, for example, Pyrido[2,3-b]pyrazine (cas: 322-46-3Electric Literature of C7H5N3).
Pyrido[2,3-b]pyrazine (cas: 322-46-3) belongs to pyrazine derivatives. Pyrazine derivatives have antitumor, antibiotic, anticonvulsant, antituberculous and diuretic effects as well as kinase, enzymatic and potent tubulin and FtsZ polymerization inhibitory activities. Pyrazine and a variety of alkylpyrazines are flavor and aroma compounds found in baked and roasted goods. Tetramethylpyrazine (also known as ligustrazine) is reported to scavenge superoxide anion and decrease nitric oxide production in human Granulocytes.Electric Literature of C7H5N3