Ring transformations of heterocyclic halo compounds with nucleophiles. XL. Pteridine studies. Part V. Dual reactivity of 2-chloro-4,6,7-triphenylpteridine and 6-chloropyrido[2,3-b]pyrazine towards potassium amide in liquid ammonia was written by Nagel, A.;Van der Plas, H. C.. And the article was included in Tetrahedron Letters in 1978.HPLC of Formula: 322-46-3 This article mentions the following:
The pteridine I (X = N, R = Cl, R1 = Ph) reacted with KNH2 in NH3(l) to give the aminodechlorinated product I (X = N, R = NH2, R1 = Ph) and the dechlorinated product I (X = N, R = H, R1 = Ph). Labeling studies showed that the aminodechlorination proceeds by a ring opening-ring closure sequence which implies that the 2-chloro substituent of I (i.e. R) directs the attack of the nucleophile exclusively to C-4. The reaction of the pyrazine I (X = CH, R = Cl, R1 = H) with KNH2 in NH3(l) was studied; I (X = CH, R = R1 = H) and the imidazopyridine II were obtained in a 1:3 ratio. The mechanism of this ring contraction is discussed and a reaction scheme postulated. In the experiment, the researchers used many compounds, for example, Pyrido[2,3-b]pyrazine (cas: 322-46-3HPLC of Formula: 322-46-3).
Pyrido[2,3-b]pyrazine (cas: 322-46-3) belongs to pyrazine derivatives. Pyrazine is an N-heterocyclic moiety, and it can be easily prepared from ethylenediamine and 1,2-diketone, α-hydroxyketone, α-methyl ketone. Pyrazine-based skeletons were incorporated into agents targeting a range of ailments. Many derivatives were synthesized and evaluated as potential cancer treatments.HPLC of Formula: 322-46-3