Synthesis and antithrombogenicity assessment of tetramethylpyrazine-polyacrylic acid conjugate was written by Lin, Nini;Wang, Song;Zhu, Hesun. And the article was included in Gaojishu Tongxun in 2005.Computed Properties of C8H12N2O This article mentions the following:
To enhance the stability and delivery in vivo of tetramethylpyrazine (TMPZ), TMPZ-polyacrylic acid (PAA) conjugate was designed and synthesized efficiently by the condensation reaction of 2,5-dihydroxymethyl-3,6-dimethylpyrazine (TMPZD2) with PAA (M = 1000) in the presence of dicyclohexylcarbodiimide (DCCI). The TMPZ-PAA conjugate was then purified and characterized by FT-IR, UV spectra. The percentage of TMPZ in the sample was 29.4% from UV absorbance at 294 nm. The anticoagulant activity of the conjugate was evaluated by in vitro coagulation time test and platelet aggregation. The APTT, PT, TT, and the time of platelet aggregation of the TMPZ-PAA conjugate took longer than those of control, exhibiting better blood anticoagulant activity. The mechanism of antithrombogenicity of TMPZ-PAA conjugate was discussed. In the experiment, the researchers used many compounds, for example, (3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3Computed Properties of C8H12N2O).
(3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3) belongs to pyrazine derivatives. Pyrazine derivatives have antitumor, antibiotic, anticonvulsant, antituberculous and diuretic effects as well as kinase, enzymatic and potent tubulin and FtsZ polymerization inhibitory activities. A number of pyrazine-based derivatives were used as dyes or fluorescent probes.Computed Properties of C8H12N2O