Ligustrazine derivatives. Part 6: design, synthesis and evaluation of novel ligustrazinyl acylguanidine derivatives as potential cardiovascular agents was written by Li, Zhenyu;Yu, Fang;Cui, Lei;Zhan, Peng;Wang, Shouxun;Shen, Yuemao;Liu, Xinyong. And the article was included in Medicinal Chemistry in 2012.Computed Properties of C8H12N2O This article mentions the following:
A series of novel Ligustrazinyl acylguanidines I [R = H, Me, C6H4Me-4, C6H4OMe-4, CH2C6H4F-4, CH2C6H4Cl-3, CH2C6H4OMe-4, CH2C6H4F-2, CH2C6H4Cl-2, CH2Ph, CH2C6H3Cl2-2,4, CH2C6H3Cl2-3,4, 3,5,6-trimethylpyrazin-2-yl] was designed, synthesized and evaluated for their protective effect on injured vascular endothelial cell (ECV-304). The preliminary results demonstrated that some compounds possessed more potent activities than that of Ligustrazine in stimulating replication of the injured endothelial cell. Among the active compounds, compounds I [R = Me, CH2C6H4Cl-3, CH2C6H3Cl2-3,4] displayed remarkable antioxidative activity with low EC50 values of 0.097, 0.059 and 0.094 mM, resp. Structure-activity relationships were briefly discussed. In the experiment, the researchers used many compounds, for example, (3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3Computed Properties of C8H12N2O).
(3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3) belongs to pyrazine derivatives. Pyrazine heterocycles and their benzo derivatives possess many interesting properties, including chemical reactivity profiles, and have diverse applications in total synthesis, medicine, chemical biology, materials, dyes, and imaging. A number of pyrazine-based derivatives were used as dyes or fluorescent probes.Computed Properties of C8H12N2O