Unified Approach to Decarboxylative Halogenation of (Hetero)aryl Carboxylic Acids was written by Chen, Tiffany Q.;Pedersen, P. Scott;Dow, Nathan W.;Fayad, Remi;Hauke, Cory E.;Rosko, Michael C.;Danilov, Evgeny O.;Blakemore, David C.;Dechert-Schmitt, Anne-Marie;Knauber, Thomas;Castellano, Felix N.;MacMillan, David W. C.. And the article was included in Journal of the American Chemical Society in 2022.HPLC of Formula: 912773-21-8 This article mentions the following:
A general catalytic method for direct decarboxylative halogenation of (hetero)aryl carboxylic acids RC(O)OH (R = 4-sulfamoylphenyl, 5-methylpyridin-2-yl, isoquinolin-1-yl, etc.) via ligand-to-metal charge transfer was reported. This strategy accommodates an exceptionally broad scope of substrates. An aryl radical intermediate is leveraged toward divergent functionalization pathways: (1) atom transfer to access bromo- or iodo(hetero)arenes or (2) radical capture by copper and subsequent reductive elimination to generate chloro- or fluoro(hetero)arenes. The proposed ligand-to-metal charge transfer mechanism is supported through an array of spectroscopic studies. In the experiment, the researchers used many compounds, for example, 2-Bromo-5-chloropyrazine (cas: 912773-21-8HPLC of Formula: 912773-21-8).
2-Bromo-5-chloropyrazine (cas: 912773-21-8) belongs to pyrazine derivatives. Pyrazine heterocycles and their benzo derivatives possess many interesting properties, including chemical reactivity profiles, and have diverse applications in total synthesis, medicine, chemical biology, materials, dyes, and imaging. Pyrazines are chemical compounds (technically called “methoxypyrazines”) found in grape skin and stems that are responsible for many “green” flavors in wine. Levels of pyrazines are dependent on viticultural practices, climate, and grape variety.HPLC of Formula: 912773-21-8