Purity of intermediate ammoniate and its influence on quality of amiloride was written by Zhang, Shengqiang;Chen, Jianming;Yu, Wenxian;Jiang, Xinru. And the article was included in Zhongguo Yaoke Daxue Xuebao in 1995.Safety of Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate This article mentions the following:
The purity of 3,5-diamino-6-chlor-2-methoxycarboxyl-pyrazine (ammoniate) was examine by HPLC. The chromatog. determination results of crude ammoniate were conformed by melting data. Ammoniate of high purity processed high m.p., the amiloride prepared with ammoniate of high purity had good quality. In the experiment, the researchers used many compounds, for example, Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate (cas: 1458-01-1Safety of Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate).
Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate (cas: 1458-01-1) belongs to pyrazine derivatives. Pyrazine heterocycles and their benzo derivatives possess many interesting properties, including chemical reactivity profiles, and have diverse applications in total synthesis, medicine, chemical biology, materials, dyes, and imaging. Substituted pyrazines have been found as subunits of multiple synthetically constructed therapeutic agents, as well as several natural products.Safety of Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate