Hydrophobicity parameter of diazines IV: a new hydrogen-accepting parameter of monosubstituted (di)azines for the relationship of partition coefficients in different solvent systems was written by Yamagami, Chisako;Fujita, Toshio. And the article was included in Journal of Pharmaceutical Sciences in 2000.Name: Ethyl pyrazine-2-carboxylate This article mentions the following:
The authors recently proposed a new H-accepting scale, SHA, for each member of the substituted (di)azine series from the heat of formation calculated under various dielec. environments by the COSMO method. The SHA scale was used to examine relations between log PCL (PCL: CHCl3/H2O partition coefficient) and log Poct (Poct: 1-octanol/H2O partition coefficient) for each of the 2-substituted pyridine (I), monosubstituted pyrazine (II), and pyrimidine (III) series. This SHA parameter worked nicely, representing the H-accepting effect of the solute mol. A correlation equation with excellent quality, such as log PCL = a log Poct + sSHA + constant, was obtained for each series. The authors further defined the parameter SHA/PY, derived from SHA values for the heterocyclic series by shifting the reference points to unsubstituted pyridine, to unify sep. derived correlation equations. Thus, the correlation between log PCL and log Poct for all combined data of three series was derived by using a single equation as log PCL = a log Poct + sSHA/PY + constant The SHA parameters were reasonably considered as being free-energy related, and the rationale for the H-bond-acceptor scale was presented. In the experiment, the researchers used many compounds, for example, Ethyl pyrazine-2-carboxylate (cas: 6924-68-1Name: Ethyl pyrazine-2-carboxylate).
Ethyl pyrazine-2-carboxylate (cas: 6924-68-1) belongs to pyrazine derivatives. Pyrazine derivatives have antitumor, antibiotic, anticonvulsant, antituberculous and diuretic effects as well as kinase, enzymatic and potent tubulin and FtsZ polymerization inhibitory activities. Substituted pyrazines have been found as subunits of multiple synthetically constructed therapeutic agents, as well as several natural products.Name: Ethyl pyrazine-2-carboxylate