Synthesis of substituted pyrazines derived from pyrazinecarboxaldehyde and hydroxymethylpyrazine was written by Piera, F.;Seoane, E.;Mestres, R.. And the article was included in Anales de Quimica (1968-1979) in 1979.SDS of cas: 6924-68-1 This article mentions the following:
From pyrazinecarboxylic and 2,3-pyrazinedicarboxylic esters were prepared from their acids. Pyrazinecarboxaldehyde (I) was obtained by LiAlH4 reduction of Me pyrazinecarboxylate (II). Pyrazinylacrylates were obtained by Wittig reactions of I and alkyl pryazinyl carbinols by Grignard reactions of I. Pyrazinylmethacrolein was prepared by reducing pyrazinylmethacrylate to the alc. and MnO2 oxidation NaBH4 reduction of II gave pyrazinemethanol which when mesylated underwent a variety of substitution reactions. In the experiment, the researchers used many compounds, for example, Ethyl pyrazine-2-carboxylate (cas: 6924-68-1SDS of cas: 6924-68-1).
Ethyl pyrazine-2-carboxylate (cas: 6924-68-1) belongs to pyrazine derivatives. Pyrazine heterocycles and their benzo derivatives possess many interesting properties, including chemical reactivity profiles, and have diverse applications in total synthesis, medicine, chemical biology, materials, dyes, and imaging. A large number of pyrazine derivatives are known for their antitumor, antibiotic, anticonvulsant, antituberculosis, and diuretic activities.SDS of cas: 6924-68-1