Synthesis of the novel ligustrazine derivatives and their protective effect on injured vascular endothelial cell damaged by hydrogen peroxide was written by Liu, Xinyong;Zhang, Rui;Xu, Wenfang;Li, Chaowu;Zhao, Quanqin;Wang, Xingpo. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2003.Formula: C8H12N2O This article mentions the following:
A series of novel 2-acyloxymethyl-3,5,6-trimethylpyrazine derivatives, e.g. I (R = Ph), was designed and synthesized. Most compounds were found to be 1.5-4.5-fold higher potency than tetramethylpyrazine (TMP) in stimulating the proliferation of normal vascular endothelial cells and in protecting against hyperoxic acute injury. The most active one is I (RCO = 2-nicotinoyl) exhibiting the maximum proliferation rate (Pmax) of 88.57% at the concentration of 0.1 mmol L-1. Structure-activity relationships of these compounds were discussed. In the experiment, the researchers used many compounds, for example, (3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3Formula: C8H12N2O).
(3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3) belongs to pyrazine derivatives. Pyrazine is an N-heterocyclic moiety, and it can be easily prepared from ethylenediamine and 1,2-diketone, α-hydroxyketone, α-methyl ketone. Pyrazine and a variety of alkylpyrazines are flavor and aroma compounds found in baked and roasted goods. Tetramethylpyrazine (also known as ligustrazine) is reported to scavenge superoxide anion and decrease nitric oxide production in human Granulocytes.Formula: C8H12N2O