Substituted pyrido[2,3-b]pyrazines was written by Kaye, Irving A.. And the article was included in Journal of Medicinal Chemistry in 1964.Electric Literature of C7H5N3 This article mentions the following:
Pyrido[2,3-b]pyrazines were prepared by condensing 2,3-diaminopyridine or 2,3,6-triaminopyridine with an α-diketone or (CO2Et)2; Pb 6-aminopyrido[2,3-b]pyrazine-2,3-dicarboxylate was obtained by KMnO4 oxidation of 6-amino-2,3-dimethylpyrido[2,3-b]pyrazine. In the experiment, the researchers used many compounds, for example, Pyrido[2,3-b]pyrazine (cas: 322-46-3Electric Literature of C7H5N3).
Pyrido[2,3-b]pyrazine (cas: 322-46-3) belongs to pyrazine derivatives. Pyrazinesare six-membered aromatic heterocyclic organic compounds with two nitrogen atoms at 1,4-positions. Pyrazine is a weaker base (pKb = 13.4) than pyridine (pKb = 8.8), pyrimidine (pKb = 12.7). Pyrazines are chemical compounds (technically called “methoxypyrazines”) found in grape skin and stems that are responsible for many “green” flavors in wine. Levels of pyrazines are dependent on viticultural practices, climate, and grape variety.Electric Literature of C7H5N3