Ligustrazine derivatives. Part 3: Design, synthesis and evaluation of novel acylpiperazinyl derivatives as potential cerebrocardiac vascular agents was written by Cheng, Xian-Chao;Liu, Xin-Yong;Xu, Wen-Fang;Guo, Xiu-Li;Zhang, Ning;Song, Yu-Ning. And the article was included in Bioorganic & Medicinal Chemistry in 2009.SDS of cas: 75907-74-3 This article mentions the following:
A series of novel acylpiperazinyl Ligustrazine derivatives was designed, synthesized, and their protective effects on damaged ECV-304 cells and antiplatelet aggregation activities were evaluated. The results showed that compound I (R = salicyloyl) displayed most potential protective effects on the ECV-304 cells damaged by hydrogen peroxide, and compound I (R = acetylsalicyloyl) was found to be the most active antiplatelet aggregation agent. Structure-activity relationships were briefly discussed. In the experiment, the researchers used many compounds, for example, (3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3SDS of cas: 75907-74-3).
(3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3) belongs to pyrazine derivatives. Pyrazine heterocycles and their benzo derivatives possess many interesting properties, including chemical reactivity profiles, and have diverse applications in total synthesis, medicine, chemical biology, materials, dyes, and imaging. Pyrazine heterocycles and their benzo derivatives possess many interesting properties, including chemical reactivity profiles, and have diverse applications in total synthesis, medicine, chemical biology, materials, dyes, and imaging.SDS of cas: 75907-74-3