Scavenging action to hydroxyl free radical of ligustrazine and it’s derivatives was written by Bian, Xiaoli;Chen, Xuemin;Liu, Yanxia;Pan, Qing. And the article was included in Zhongguo Yiyuan Yaoxue Zazhi in 2003.Reference of 75907-74-3 This article mentions the following:
The hydroxyl free radical scavenging activity of ligustrazine and its derivatives (2-hydromethyl-3,5,6- trimethylpyrazine, tetramethylpyrazine-N-monoxygen and tetramethylpyrazine-N-dioxygen) were evaluated using Fenton reaction to assay and calculate the concentration of compounds for scavenging 50% of hydroxyl free radicals (EC50). In scavenging action to ·OH, a significant difference was observes between the ligustrazine as well as its derivatives and benzoic acid and mannitol (P <0.01), however, there was no apparent difference between ligustrazine and its derivatives (P >0.05). Ligustrazine and its derivatives had strong scavenging action to hydroxyl free radical. In the experiment, the researchers used many compounds, for example, (3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3Reference of 75907-74-3).
(3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3) belongs to pyrazine derivatives. Pyrazine is an N-heterocyclic moiety, and it can be easily prepared from ethylenediamine and 1,2-diketone, α-hydroxyketone, α-methyl ketone. A number of pyrazine-based derivatives were used as dyes or fluorescent probes.Reference of 75907-74-3