Degradation behavior of poly(ethylene glycol) dicarboxylic acid (2-hydroxymethyl-3,5,6-trimethylpyrazine) ester in vitro was written by Xia, Cheng-jian;Wang, Song;Zhu, He-sun. And the article was included in Jingxi Huagong in 2004.Formula: C8H12N2O This article mentions the following:
Poly(ethylene glycol) (PEG) dicarboxylic acid (2-hydroxymethyl-3,5,6-trimethylpyrazine) ester (patented by BIT) was prepared in 92% yield by condensation of PEG-10000 and 2-hydroxymethyl-3,5,6-trimethylpyrazine with 1,1′-carbonyldiimidazole (CDI) as condensating agent. The product was characterized by m.p., FTIR and 1HNMR: m.p. 53 â?55 °C; FTIR absorption 1747 cm-1 (C=O), 1254 cm-1 (C-O-C); 1HNMR δ = 1.9 (-CH3, 3H, s), 2.2 (-CH3, 6H, s), 4.2 (-CH2-, 2H, s), 3.6 (-OCH2-, multi – H, s). The hydrolytic degradation of the ester in vitro was performed and results indicated that the degradation rate was pH-dependent. In the experiment, the researchers used many compounds, for example, (3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3Formula: C8H12N2O).
(3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3) belongs to pyrazine derivatives. Pyrazine is a symmetrical molecule with point group D2h. Pyrazine is less basic than pyridine, pyridazine and pyrimidine. Pyrazines are chemical compounds (technically called âmethoxypyrazinesâ? found in grape skin and stems that are responsible for many âgreenâ?flavors in wine. Levels of pyrazines are dependent on viticultural practices, climate, and grape variety.Formula: C8H12N2O