Synthesis of 2-hydroxymethyl-3,5,6-trimethylpyrazine grafted by polyethylene glycol was written by Xia, Cheng-jian;Wang, Song;Zhu, He-sun. And the article was included in Jingxi Huagong in 2004.Name: (3,5,6-Trimethylpyrazin-2-yl)methanol This article mentions the following:
Polyethylene glycol grafted 2-hydroxymethyl-3,5,6-trimethylpyrazine is prepared in 69% yield by condensation of polyethylene glycol dicarboxylic acid and 2-hydroxymethyl-3,5,6-trimethylpyrazine with dicydohexylcarbodiimide (DCCI) as condensating agent. The product is characterized by m.p., FTIR and 1HNMR; m. p. 45 â?48 °C; IR absorption 1747 cm-1 (C = O), 1254 cm-1 (C-O-C); 1HNMR â?= 1.9 (-CH3, 3H, s), 2.2 (-CH3, 6H, s), 4.2 (CH2-, 2H, s), 3.6 (-OCH2-, multi-H, s). In the experiment, the researchers used many compounds, for example, (3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3Name: (3,5,6-Trimethylpyrazin-2-yl)methanol).
(3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3) belongs to pyrazine derivatives. Pyrazine is an N-heterocyclic moiety, and it can be easily prepared from ethylenediamine and 1,2-diketone, α-hydroxyketone, α-methyl ketone. Pyrazines undergo nearly all of the same reactions as pyrimidines, from nucleophilic substitution (SNAr) to palladium-catalyzed cross coupling reactions.Name: (3,5,6-Trimethylpyrazin-2-yl)methanol