Design and synthesis of potent carboxylic acid DGAT1 inhibitors with high cell permeability was written by Bali, Ustav;Barba, Oscar;Dawson, Graham;Gattrell, William T.;Horswill, James G.;Pan, David A.;Procter, Martin J.;Rasamison, Chrystelle M.;Sambrook Smith, Colin P.;Taylor-Warne, Amanda;Wong-Kai-In, Philippe. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2012.Product Details of 1209459-10-8 This article mentions the following:
A series of potent carboxylic acid, e.g., I, as DGAT1 inhibitors with high permeability were developed from a virtual screening hit. Strategies were employed to reduce Pgp substrate recognition and increase passive permeability, resulting in the discovery of a series showing good inhibition of cellular triglyceride synthesis. The mutagenic potential of prospective metabolites was evaluated and one aniline was shown to be devoid of mutagenicity. In the experiment, the researchers used many compounds, for example, 2-Bromo-5-fluoropyrazine (cas: 1209459-10-8Product Details of 1209459-10-8).
2-Bromo-5-fluoropyrazine (cas: 1209459-10-8) belongs to pyrazine derivatives. Pyrazines are volatile compounds that are used in the cosmetic, food, flavor, and fragrance industries. A number of pyrazine-based derivatives were used as dyes or fluorescent probes.Product Details of 1209459-10-8