Electrophysiological studies of pyridine-sensitive units on the crayfish walking leg. I. Characteristics of stimulatory molecules was written by Hatt, H.;Schmiedel-Jakob, I.. And the article was included in Journal of Comparative Physiology, A: Sensory, Neural, and Behavioral Physiology in 1984.Computed Properties of C7H5N3 This article mentions the following:
Pyridine-sensitive units located on the walking legs of the crayfish Austropotamobius torrentium were studied by extracellular recording of the action potentials of single afferent fibers. To characterize the sensitivity and specificity of the pyridine receptor, 79 pyridine analogs and other related substances were tested on 70 neurons. The maximum impulse frequency of the response was used to construct dose-response curves. The effectiveness of stimulatory substances was characterized at the half-maximal-response frequency, KM. The effectiveness rank order of the substances was the same for all units tested. The most effective substances were: pyrazinecarboxamide > 3-acetylpyridine > nicotinamide > pyridine-3-aldoxime, with KM values of 1.5 × 10-6, 4 × 10-6, 10-5, and 4 × 10-5M, resp. The inferred structural requirements for an optimal stimulatory mol. are that it have an N-containing aromatic ring system with a specific substituent in the m position. In the experiment, the researchers used many compounds, for example, Pyrido[2,3-b]pyrazine (cas: 322-46-3Computed Properties of C7H5N3).
Pyrido[2,3-b]pyrazine (cas: 322-46-3) belongs to pyrazine derivatives. Pyrazine heterocycles and their benzo derivatives possess many interesting properties, including chemical reactivity profiles, and have diverse applications in total synthesis, medicine, chemical biology, materials, dyes, and imaging. Pyrazines are chemical compounds (technically called “methoxypyrazines”) found in grape skin and stems that are responsible for many “green” flavors in wine. Levels of pyrazines are dependent on viticultural practices, climate, and grape variety.Computed Properties of C7H5N3