Month: November 2022

Chen, Erbao published the artcileAnalysis of aroma components from sugarcane to non-centrifugal cane sugar using GC-O-MS, COA of Formula: C7H10N2, the main research area is aroma component sugarcane non centrifugal cane sugar.

A total of 84 volatile aroma components were determined in the 9 samples of sugarcane to non-centrifugal sugar (NCS), including 15 alcs., 12 aldehydes, 10 ketones, 17 carboxylic acids, 11 pyrazines, 7 phenols, 3 esters, 3 hydrocarbons, and 2 sulfur compounds Of these compounds, 10 were with high flavor dilution (FD) factors based on the aroma extract dilution anal. (AEDA). 4-Hydroxy-2,5-dimethyl-3(2H)furanone exhibited the highest FD factor of 2187, followed by (E)-2-nonenal, 2-hydroxy-3-methyl-2-cyclopentene-1-one, and 4-allyl-2,6-dimethoxyphenol with a FD factor of 729. The odor compounds showed no significant change and were similar to that of sugarcane during the first four steps in the production of non-centrifugal cane sugar. In the middle three stages, the heating slightly affected the aroma composition Addnl., a prolonged period of high-temperature heating, lead to the production of the Maillard reaction products, such as pyrazines, pyrroles, and furans, differentiating the step to be unique from the previous seven stages. However, the content of the NCS odorants was significantly reduced due to the loss of odor compounds during the drying process.

RSC Advances published new progress about Aldehydes Role: BUU (Biological Use, Unclassified), BIOL (Biological Study), USES (Uses). 14667-55-1 belongs to class pyrazines, name is 2,3,5-Trimethylpyrazine, and the molecular formula is C7H10N2, COA of Formula: C7H10N2.

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Peixoto, Vanessa Oliveira Di-Sarli published the artcileBaru (Dipteryx alata vogel) oil extraction by supercritical-CO2: improved composition by using water as cosolvent, Computed Properties of 14667-55-1, the main research area is Dipteryx alata vogel oil extraction supercritical carbon dioxide cosolvent; baru almond; polar cosolvent; volatile compounds profile; β-sitosterol; γ-tocopherol.

Baru (Dipteryx alata) almond is an emerging nut from the Brazilian savannah, that presents unique flavor and an interesting specialty oil. In this study, we aimed at investigating the effects of pressure, temperature, type (alc. and/or water), and concentration of polar cosolvent on the extraction yield and tocopherol contents of baru oil obtained by supercritical-CO2 extraction (SC-CO2); and to investigate the effect of temperature and pressure on phytosterol, phenolic, and volatile compounds’ profile in the oil when H2O was the cosolvent. Baru oil extracted with SC-CO2 using alc. as a cosolvent showed a higher extraction yield (20.5-31.1%) than when using H2O (4.16-22.7%). However, when 0.3% H2O was used as cosolvent, baru oils presented the highest γ-tocopherol (107 and 43.7 mg/100 g) and total tocopherol (212 and 48.7 mg/100 g) contents, depending on the temperature and pressure used (50°C and 10 MPa or 70°C and 30 MPa, resp.). Consequently, the lowest pressure (10 MPa) and temperature (50°C) values resulted in baru oils with better γ/α-ratio, and the highest contents of β-sitosterol (107 mg/100 g) and phenolic compounds (166 mg/100 g). However, the highest pressure (30 MPa) and temperature (70°C) values improved the volatile profile of oils. Therefore, although alc. as a cosolvent improved oil yield, small amounts of H2O provided a value-added baru oil with either high content of bioactive compounds or with a distinctive volatile profile by tuning temperature and pressure used during SC-CO2 extraction

Journal of Oleo Science published new progress about Aldehydes Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 14667-55-1 belongs to class pyrazines, name is 2,3,5-Trimethylpyrazine, and the molecular formula is C7H10N2, Computed Properties of 14667-55-1.

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Sanchez-Monedero, M. A. published the artcileBiochar reduces volatile organic compounds generated during chicken manure composting, Formula: C7H10N2, the main research area is biochar volatile organic compound chicken manure composting; Health risk; Methoxyphenyloxime; Pollutants; SPME; VOC; Volatilisation.

The efficiency of biochar for reducing the levels of volatile organic compounds (VOC) was investigated in a composting mixture containing 90% poultry manure and 10% straw (with and without 3% biochar addition) at three different stages of the process. The use of a low application rate of biochar reduced the concentration of VOC during the thermophilic phase. Biochar significantly reduced the levels of nitrogen volatile compounds, which are the most abundant VOC family, originated from microbial transformation of the N-compounds originally present in manure. The most efficient VOC reduction was observed in oxygenated volatile compounds (ketones, phenols and organic acids), which are intermediates of organic matter degradation, whereas there was no effect on other VOC families (aliphatic, aromatic and terpenes). These results suggest the importance of not only the sorption capacity of biochar but also its impact in the composting progress as main drivers for VOC reduction

Bioresource Technology published new progress about Composting wastewater treatment. 14667-55-1 belongs to class pyrazines, name is 2,3,5-Trimethylpyrazine, and the molecular formula is C7H10N2, Formula: C7H10N2.

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Ma, Yun-Jiao published the artcileEffect of alkyl distribution in pyrazine on pyrazine flavor release in bovine serum albumin solution, Application of 2,3,5-Trimethylpyrazine, the main research area is pyrazine alkyl distribution flavor bovine serum albumin.

The flavor release mechanism related to the interaction of aroma compounds with proteins is still unclear. In this study, the interaction of protein with pyrazine homologues, such as 2-methylpyrazine (MP), 2,5-dimethylpyrazine (DP), 2,3,5-trimethylpyrazine (TRP) and 2,3,5,6-tetramethylpyrazine (TEP), was investigated to elucidate the effect of alkyl distribution in a pyrazine ring on its flavor release in bovine serum albumin (BSA) solution (pH 7.4). The results of SPME-GC-MS indicated that Me distribution in a pyrazine ring significantly affected its release from BSA solution The pyrazines released from BSA solution with an increasing order of MP, DP, TRP and TEP. The inhibition mechanism of alkyl-pyrazine release was further elucidated by the interaction between alkyl-pyrazines and BSA using multiple spectroscopic methods. The non-covalent interaction between alkyl-pyrazines and BSA was confirmed as the main interaction force by the value of the bimol. quenching constant (Kq > 2 * 1010 L mol-1 s-1). A decrease in the hydrophobicity of the microenvironment between the alkyl-pyrazine and BSA was detected by synchronous fluorescence spectra, which revealed that alkyl-pyrazines were mainly bound on the sites of tyrosine and tryptophan in BSA. The UV-vis absorption spectra and circular dichromatic (CD) spectrum revealed that alkyl-pyrazines could induce polarity and conformation change of BSA. The above results indicated that the structure of the flavor homologues can affect their release in food matrixes.

RSC Advances published new progress about Circular dichroism. 14667-55-1 belongs to class pyrazines, name is 2,3,5-Trimethylpyrazine, and the molecular formula is C7H10N2, Application of 2,3,5-Trimethylpyrazine.

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Ahmed, Ammar published the artcileUsing volatile organic compounds to investigate the effect of oral iron supplementation on the human intestinal metabolome, COA of Formula: C7H10N2, the main research area is human intestinal metabolome volatile organic compound iron oral supplementation; gut microbiome; intestinal metabolome; iron deficiency anaemia; iron supplementation; volatile organic compounds (VOCs).

Patients with iron deficiency anemia are treated with oral iron supplementation, which is known to cause gastrointestinal side effects by likely interacting with the gut microbiome. To better study this impact on the microbiome, we investigated oral iron-driven changes in volatile organic compounds (VOCs) in the faecal metabolome. Stool samples from patients with iron deficiency anemia were collected pre- and post-treatment (n = 45 and 32, resp.). Faecal headspace gas anal. was performed by gas chromatog.-mass spectrometry and the changes in VOCs determined We found that the abundance of short-chain fatty acids and esters fell, while aldehydes increased, after treatment. These changes in pre- vs. post-iron VOCs resemble those reported when the gut is inflamed. Our study shows that iron changes the intestinal metabolome, we suggest by altering the structure of the gut microbial community.

Molecules published new progress about Anemia. 14667-55-1 belongs to class pyrazines, name is 2,3,5-Trimethylpyrazine, and the molecular formula is C7H10N2, COA of Formula: C7H10N2.

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Bis-Souza, Camila Vespucio published the artcileVolatile profile of fermented sausages with commercial probiotic strains and fructooligosaccharides, HPLC of Formula: 14667-55-1, the main research area is fructooligosaccharide butanoic acid fermented sausage probiotic Lactobacillus food; Aroma; FOS; Lactic acid bacteria; Meat product; Prebiotic; Volatile compounds.

The effect of the partial substitution of pork back fat by fructooligosaccharides (FOS) and the probiotic strains Lactobacillus paracasei and Lactobacillus rhmanosus on the generation of volatile organic compounds in fermented sausages was investigated. The results obtained showed that these factors significantly affected the total content of organic volatile compounds (7484, 8114, 8372 and 10,737 AU × 104/g for FOS.GG, CON, FOS.BGP1 and FOS samples, resp.). A total of 59 volatile components, mainly hydrocarbons, ketones and esters were isolated. The reduction of fat content by including FOS in the formulation results in pos. effects and a greater stability of the volatile profile of the fermented sausages, increasing ester compounds and reducing the undesirable notes of hexanal (probiotic samples showed values < 2 AU × 104/g). Moreover, there was a symbiotic effect when the aforementioned prebiotic fiber was combined with probiotic Lactobacillus strains. Journal of Food Science and Technology (New Delhi, India) published new progress about Fructooligosaccharides Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 14667-55-1 belongs to class pyrazines, name is 2,3,5-Trimethylpyrazine, and the molecular formula is C7H10N2, HPLC of Formula: 14667-55-1.

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Chen, Mingjie published the artcileAnalyzing changes of volatile components in dried pork slice by gas chromatography-ion mobility spectroscopy, Application In Synthesis of 14667-55-1, the main research area is volatile component dried pork slice gas chromatographyion mobility spectroscopy.

The volatile organic compounds (VOCs) in different processing stages of dried pork slices (DPS) were analyzed by gas chromatog.-ion mobility spectrometry (GC-IMS), which was used to construct the GC-IMS odor fingerprint spectrometry. The VOCs of raw meat, mixed meat, cured meat, semi-finished meat and finished meat were detected and analyzed by GC-IMS. The result shows that the main VOC species in DPS include alcs. and aldehydes, acids, ketones, heterocyclic compounds, aromatic hydrocarbons and esters. Except that the VOCs of mixed meat and cured meat were very similar, the odor component characteristics of DPS in other processing stages were significantly different. GC-IMS technol. can effectively distinguish the volatile component differences of preserved meat samples at different processing stages. It is of profound significance to regulate and ensure the consistency of the VOCs in the processing of DPS.

CyTA–Journal of Food published new progress about. 14667-55-1 belongs to class pyrazines, name is 2,3,5-Trimethylpyrazine, and the molecular formula is C7H10N2, Application In Synthesis of 14667-55-1.

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Zhang, Wenqing published the artcileHepatoprotective ability of tetramethylpyrazine produced by Bacillus amyloliquefaciens, COA of Formula: C7H10N2, the main research area is Bacillus tetramethylpyrazine hepatoprotective ability.

Tetramethylpyrazine (TTMP), an important aroma compound, was produced by Bacillus amyloliquefaciens XJB-104 with distillers’ grains as raw material. The yield of TTMP under optimized fermentation procedure was 3176.52 mg/L. TTMP in the fermentation broth was purified and the purity (> 99%) was measured by gas chromatog.-mass spectrometry. Furthermore, the hepatoprotective activity of TTMP in ethanol-water system was evaluated by biochem. indicators of liver injury, parameters of antioxidant defense system and inflammatory response, and liver histopathol. assessment in mice. Ethanol treatment increased serum levels of alanine aminotransferase, aspartate aminotransferase, alk. phosphatase and lactate dehydrogenase, suggesting liver damage. Both high and low dose of TTMP significantly decreased levels of these indicators. Furthermore, the reduction in the activities or concentrations of superoxide dismutase, catalase, reduced glutathione and malondialdehyde in liver tissue caused by ethanol was significantly alleviated by TTMP. Increased inflammatory cytokines including transcription factor, tumor necrosis factor, interleukin-1beta, interleukin, macrophage chemoattractant protein, inducible nitric oxide synthase and cyclooxygenase were also suppressed by TTMP treatment. It is concluded that TTMP in ethanol-water system has potential liver-protective activity, especially when ethanol is consumed at low doses for short periods of time.

Systems Microbiology and Biomanufacturing published new progress about Antioxidants. 14667-55-1 belongs to class pyrazines, name is 2,3,5-Trimethylpyrazine, and the molecular formula is C7H10N2, COA of Formula: C7H10N2.

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Mhlongo, Msizi I. published the artcileProfiling of Volatile Organic Compounds from Four Plant Growth-Promoting Rhizobacteria by SPME-GC-MS: A Metabolomics Study, SDS of cas: 14667-55-1, the main research area is PGPR volatile organic compound metabolomics profiling SPME GCMS; metabolomics profiling; multivariate data analysis (MVDA); plant growth promoting rhizobacteria (PGPR); solid-phase micro-extraction gas chromatography mass spectrometry (SPME–GC–MS); volatile organic compounds (VOCs).

The rhizosphere microbiome is a major determinant of plant health. Plant-beneficial or plant growth-promoting rhizobacteria (PGPR) influence plant growth, plant development and adaptive responses, such as induced resistance/priming. These new eco-friendly choices have highlighted volatile organic compounds (biogenic VOCs) as a potentially inexpensive, effective and efficient substitute for the use of agrochems. Secreted bacterial VOCs are low mol. weight lipophilic compounds with a low b.p. and high vapor pressures. As such, they can act as short- or long-distance signals in the rhizosphere, affecting competing microorganisms and impacting plant health. In this study, secreted VOCs from four PGPR strains (Pseudomonas koreensis (N19), Ps. fluorescens (N04), Lysinibacillus sphaericus (T19) and Paenibacillus alvei (T22)) were profiled by solid-phase micro-extraction gas chromatog. mass spectrometry (SPME-GC-MS) combined with a multivariate data anal. Metabolomic profiling with chemometric analyses revealed novel data on the composition of the secreted VOC blends of the four PGPR strains. Of the 121 annotated metabolites, most are known as bioactives which are able to affect metabolism in plant hosts. These VOCs belong to the following classes: alcs., aldehydes, ketones, alkanes, alkenes, acids, amines, salicylic acid derivatives, pyrazines, furans, sulfides and terpenoids. The results further demonstrated the presence of species-specific and strain-specific VOCs, characterized by either the absence or presence of specific VOCs in the different strains. These mols. could be further investigated as biomarkers for the classification of an organism as a PGPR and selection for agricultural use.

Metabolites published new progress about Alcohols Role: ANT (Analyte), PUR (Purification or Recovery), ANST (Analytical Study), PREP (Preparation). 14667-55-1 belongs to class pyrazines, name is 2,3,5-Trimethylpyrazine, and the molecular formula is C7H10N2, SDS of cas: 14667-55-1.

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Wang, Likun published the artcileDivergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors, Product Details of C9H9ClIN3, the main research area is divergent allosteric control IRE1 endoribonuclease kinase.

Under endoplasmic reticulum stress, unfolded protein accumulation leads to activation of the endoplasmic reticulum transmembrane kinase/endoRNase IRE1α. IRE1α oligomerizes, autophosphorylates and initiates splicing of XBP1 mRNA, thus triggering the unfolded protein response (UPR). Here we show that IRE1α’s kinase-controlled RNase can be regulated in two distinct modes with kinase inhibitors: one class of ligands occupies IRE1α’s kinase ATP-binding site to activate RNase-mediated XBP1 mRNA splicing even without upstream endoplasmic reticulum stress, whereas a second class can inhibit the RNase through the same ATP-binding site, even under endoplasmic reticulum stress. Thus, alternative kinase conformations stabilized by distinct classes of ATP-competitive inhibitors can cause allosteric switching of IRE1α’s RNase-either on or off. As dysregulation of the UPR has been implicated in a variety of cell degenerative and neoplastic disorders, small-mol. control over IRE1α should advance efforts to understand the UPR’s role in pathophysiol. and to develop drugs for endoplasmic reticulum stress-related diseases.

Nature Chemical Biology published new progress about Aromatic nitrogen heterocycles Role: BSU (Biological Study, Unclassified), PRP (Properties), SPN (Synthetic Preparation), BIOL (Biological Study), PREP (Preparation) (kinase inhibitors). 1320266-92-9 belongs to class pyrazines, name is 8-Chloro-1-iodo-3-isopropylimidazo[1,5-a]pyrazine, and the molecular formula is C9H9ClIN3, Product Details of C9H9ClIN3.

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem