Facile one-pot synthesis of the pyrazolo[1,5-a]pyrazine scaffold was written by Zaremba, O. V.;Gorobets, N. Yu.;Kovalenko, S. S.;Drushlyak, O. G.;Grevtsov, O. Yu.;Kovalenko, S. M.. And the article was included in Chemistry of Heterocyclic Compounds in 2013.Category: pyrazines The following contents are mentioned in the article:
A series of novel pyrazolo[1,5-a]pyrazine derivatives I was synthesized using a facile one-pot three-step protocol starting from pyrazole-3-carboxylic acids. The process occurs via amide formation with consequent pyrazine ring closure, hydrolysis, and dehydration. 7-Hydroxy-6,7-dihydropyrazolo[1,5-a]-pyrazin-4(5H)-one and 7-methoxy-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one were isolated as intermediate compounds This study involved multiple reactions and reactants, such as 2-Methylpyrazolo[1,5-a]pyrazin-4(5H)-one (cas: 1314920-48-3Category: pyrazines).
2-Methylpyrazolo[1,5-a]pyrazin-4(5H)-one (cas: 1314920-48-3) belongs to pyrazine derivatives. Pyrazinesare six-membered aromatic heterocyclic organic compounds with two nitrogen atoms at 1,4-positions. Pyrazine is a weaker base (pKb = 13.4) than pyridine (pKb = 8.8), pyrimidine (pKb = 12.7). Substituted pyrazines have been found as subunits of multiple synthetically constructed therapeutic agents, as well as several natural products.Category: pyrazines