Zhou, Ping published the artcilePyridinyl aminohydantoins as small molecule BACE1 inhibitors, Application In Synthesis of 762263-64-9, the publication is Bioorganic & Medicinal Chemistry Letters (2010), 20(7), 2326-2329, database is CAplus and MEDLINE.
A novel class of pyridinyl aminohydantoins was designed and prepared as highly potent BACE1 inhibitors. Compound (S)-4g showed excellent potency with IC50 of 20 nM for BACE1. X-ray crystallog. indicated that the interaction between pyridine nitrogen and the tryptophan Trp76 was a key feature in the S2′ region of the enzyme that contributed to increased potency.
Bioorganic & Medicinal Chemistry Letters published new progress about 762263-64-9. 762263-64-9 belongs to pyrazines, auxiliary class Pyrazine,Boronic acid and ester,Boronic Acids, name is Pyrazin-2-ylboronic acid, and the molecular formula is C14H12O3S, Application In Synthesis of 762263-64-9.
Referemce:
https://en.wikipedia.org/wiki/Pyrazine,
Pyrazine | C4H4N2 – PubChem