Zeng, Qingbei’s team published research in Bioorganic & Medicinal Chemistry Letters in 23 | CAS: 762263-64-9

Bioorganic & Medicinal Chemistry Letters published new progress about 762263-64-9. 762263-64-9 belongs to pyrazines, auxiliary class Pyrazine,Boronic acid and ester,Boronic Acids, name is Pyrazin-2-ylboronic acid, and the molecular formula is C12H9NO, Computed Properties of 762263-64-9.

Zeng, Qingbei published the artcileSynthesis and SAR studies of benzimidazolone derivatives as histamine H3-receptor antagonists, Computed Properties of 762263-64-9, the publication is Bioorganic & Medicinal Chemistry Letters (2013), 23(21), 6001-6003, database is CAplus and MEDLINE.

A novel series of benzimidazolone-containing histamine H3-receptor antagonists were prepared and their structure-activity relationship was explored. These benzimidazolone analogs demonstrate potent H3-receptor binding affinities, no P 450 enzyme inhibition, and strong H3 functional activity. Compound I exhibits the best overall profile with H3Ki = 0.95 nM and rat AUC = 12.9 μM h.

Bioorganic & Medicinal Chemistry Letters published new progress about 762263-64-9. 762263-64-9 belongs to pyrazines, auxiliary class Pyrazine,Boronic acid and ester,Boronic Acids, name is Pyrazin-2-ylboronic acid, and the molecular formula is C12H9NO, Computed Properties of 762263-64-9.

Referemce:
https://en.wikipedia.org/wiki/Pyrazine,
Pyrazine | C4H4N2 – PubChem