Yun, Yanghwan published the artcile2-thioxothiazolidin-4-one analogs as pan-PIM kinase inhibitors, Quality Control of 343856-62-2, the publication is Chemical & Pharmaceutical Bulletin (2021), 69(9), 854-861, database is CAplus.
Proviral integration site for Moloney murine leukemia virus (PIM) kinases are proto-oncogenic kinases involved in the regulation of several cellular processes. PIM kinases are promising targets for new drug development because they play a major role in many cancer-specific pathways, such as survival, apoptosis, proliferation, cell cycle regulation, and migration. Here, 2-thioxothiazolidin-4-one derivatives I (R = cyclopentylamine, cyclohexyloxy, (CH2)2N(CH2)2NH, etc.; X = S) were synthesized and evaluated as potent pan-PIM kinase inhibitors. Optimized compounds showed single-digit nanomolar IC50 values against all three PIM kinases with high selectivity over 14 other kinases. Compound I (R = (CH2)2N(CH2)2NH; X = S) inhibited the growth of Molm-16 cell lines (EC50 = 14 nM) and modulated the expression of pBAD and p4EBP1 in a dose-dependent manner.
Chemical & Pharmaceutical Bulletin published new progress about 343856-62-2. 343856-62-2 belongs to pyrazines, auxiliary class Pyrazine,Piperidine,Chloride, name is 2-Chloro-6-(piperidin-1-yl)pyrazine, and the molecular formula is C10H15NS, Quality Control of 343856-62-2.
Referemce:
https://en.wikipedia.org/wiki/Pyrazine,
Pyrazine | C4H4N2 – PubChem