Vontor, T. published the artcileAntituberculotics. XLI. Functional derivatives of 5-alkyl-2-pyrazinecarboxylic acid, Application of Pyrazine-2-carbothioamide, the publication is Cesko-Slovenska Farmacie (1987), 36(6), 277-80, database is CAplus.
Amides of 5-alkyl-2-carboxypyrazines (I, R = Pr, iso-Pr, Bu, iso-Bu; R1 = H; X = O) were converted into hydrazides (I, R1 = NH2; X = O) by hydrazinolysis and also into thioamides (I, R1 = H; X = S) (II) by reaction the with P2S5. Minimal inhibitory concentrations of I were determined in cultures of Mycobacterium, tuberculosis, M. kansasii, M. avium, and M. fortuitum. The greatest in vitro tuberculostatic activity was seen with II (R = Pr). In mice exptl., infected with M. tuberculosis, therapeutic effects were obtained with I (R = iso-Pr; R1 = H; X = O) and II (R = iso-Pr). Acute i.p. toxicities in mice for these 2 compounds were 325 and 196 mg/kg, resp. Structure-activity relations are discussed.
Cesko-Slovenska Farmacie published new progress about 4604-72-2. 4604-72-2 belongs to pyrazines, auxiliary class Pyrazine,Amine,Amide, name is Pyrazine-2-carbothioamide, and the molecular formula is C21H37BO, Application of Pyrazine-2-carbothioamide.
Referemce:
https://en.wikipedia.org/wiki/Pyrazine,
Pyrazine | C4H4N2 – PubChem