Shepard, Charles C. published the artcileAn experimental study of the antileprosy activity of a series of thioamides in the mouse, Application of Pyrazine-2-carbothioamide, the publication is International Journal of Leprosy and Other Mycobacterial Diseases (1985), 53(4), 587-94, database is CAplus.
A series of substituted thioamides were studied to establish whether their structure-activity pattern against Mycobacterium leprae is similar to that previously observed against M. tuberculosis. Antileprosy activity was evaluated in the mouse foot pad test. Ethionamide (I) [536-33-4] and prothionamide (II) [14222-60-7] were approx. equipotent and the most active; thioisonicotinamide [2196-13-6] was 5-fold less active; N-hydroxymethylethionamide [4536-43-0] was also active, but 2-tert-butylthioisonicotinamide [102127-71-9], 2-dimethylaminothioisonicotinamide [102127-72-0], and pyrazine carbonic thioamide [4604-72-2] were inactive at the dosages tested. High-pressure liquid chromatog. methods were devised to study the potential influence of pharmacol. factors on their in vivo activity. All of the thioamides tested when administered orally were well absorbed and when administered i.v. were rapidly eliminated. Differences in the elimination rates for these compounds appeared to play only a minor role in affecting their relative antileprosy activities. It is concluded that the structural requirements for antileprosy and antituberculosis activity of the thioamides are probably similar.
International Journal of Leprosy and Other Mycobacterial Diseases published new progress about 4604-72-2. 4604-72-2 belongs to pyrazines, auxiliary class Pyrazine,Amine,Amide, name is Pyrazine-2-carbothioamide, and the molecular formula is C6H8O3, Application of Pyrazine-2-carbothioamide.
Referemce:
https://en.wikipedia.org/wiki/Pyrazine,
Pyrazine | C4H4N2 – PubChem