Seko, Norihiko published the artcileSynthesis and platelet aggregation inhibitory activity of diphenylazole derivatives. I. Thiazole and imidazole derivatives, COA of Formula: C5H5N3S, the publication is Chemical & Pharmaceutical Bulletin (1991), 39(3), 651-7, database is CAplus and MEDLINE.
Diphenylimidazoles I (X = NH, R = OMe, R1 = 2-, 3-, 4-pyridyl, 6-methyl-2-pyridyl, 2-, 3-thienyl, 5-methyl-2-thienyl, 3-methyl-2-thienyl, 2-pyrrolyl, 1,5-dimethyl-2-pyrrolyl) were prepared by the cyclocondensation of p-anisil with R1CHO in the presence of NH4OAc. Diphenylthiazoles I (X = S; R = OMe, H, F, SMe; R1 = as above) were prepared by the cyclocondensation of p-RC6H4COCHBrC6H4R-p with R1C(:S)NH2. I (X = NH, S) were tested as inhibitors of platelet aggregation in in vitro experiments Diphenylthiazoles I (X = S) were more potent than diphenylimidazoles I (X = NH) in inhibiting arachidonic acid-induced platelet aggregation of rabbit platelet-rich plasma. Two diphenylimidazole and eight diphenylthiazole derivatives were evaluated for ex vivo arachidonic acid and collagen-induced platelet aggregation inhibitory activity using guinea pigs. I (R = OMe, R1 = 1,5-dimethylpyrrol-2-yl, X = S) (II) showed strong activity in vitro and ex vivo. The ex vivo activity of II was 200 times stronger than that of aspirin.
Chemical & Pharmaceutical Bulletin published new progress about 4604-72-2. 4604-72-2 belongs to pyrazines, auxiliary class Pyrazine,Amine,Amide, name is Pyrazine-2-carbothioamide, and the molecular formula is C20H28B2O4S2, COA of Formula: C5H5N3S.
Referemce:
https://en.wikipedia.org/wiki/Pyrazine,
Pyrazine | C4H4N2 – PubChem