Rooney, C. S. published the artcileInhibitors of glycolic acid oxidase. 4-Substituted 3-hydroxy-1H-pyrrole-2,5-dione derivatives, COA of Formula: C5H5N3S, the publication is Journal of Medicinal Chemistry (1983), 26(5), 700-14, database is CAplus and MEDLINE.
The title compounds I (R = aryl, aryloxy, heterocycle, etc.; R1 = H, Me, or Ph) and related ones were prepared and evaluated as orally absorbable inhibitors of glycolic acid oxidase (GAO) [9028-71-1] and to examine their effect on oxalate production in animals. Inhibitors of GAO are of interest as potentially useful drugs for treatment of Ca oxalate renal lithiasis and the primary hyperoxalurias. Rat liver perfusion with 3 of the most potent I have shown effective inhibition of the conversion of glycolate to oxalate in this organ. 4-(4‘-Bromo[1,1‘-biphenyl]-4-yl)-3-hydroxy-1H-pyrrole-2,5-dione (I; R = C6H4-4-(4-BrC6H4); R1 = H) [77529-42-1] administered orally to ethylene glycol treated rats showed reduction in oxalate excretion in urine. QSAR are discussed.
Journal of Medicinal Chemistry published new progress about 4604-72-2. 4604-72-2 belongs to pyrazines, auxiliary class Pyrazine,Amine,Amide, name is Pyrazine-2-carbothioamide, and the molecular formula is C5H5N3S, COA of Formula: C5H5N3S.
Referemce:
https://en.wikipedia.org/wiki/Pyrazine,
Pyrazine | C4H4N2 – PubChem