Novacek, Libor published the artcileAntituberculotics. XII. Functional derivatives of ring-substituted pyrazinecarboxylic acids, Computed Properties of 4604-72-2, the publication is Acta Facultatis Pharmaceuticae Universitatis Comenianae (1975), 27(5), 73-87, database is CAplus.
The most active of a series of 20 ring-substituted pyrazinecarboxylic acid derivatives tested in vitro against Mycobacterium tuberculosis H37Rv, M. avium, and M. kansasii were 3-hydrazinopyrazine-2-carboxylic acid hydrazide (I) [21279-74-3], 5-bromopyrazine-2-carboxamide [36070-84-5], and 5-(vanillidenehydrazino)pyrazine-2-carboxylic acid 2-vanillidenehydrazide [36805-05-7]. For example, I was active against M. tuberculosis and M. kansasii at 25 μg/ml and against M. avium at 50 μg/ml. The acid hydrazides tested were generally more active than amides and thioamides. None of 3 of the most active compounds, tested in vivo in mice, was as potent as pyrazinamide [98-96-4].
Acta Facultatis Pharmaceuticae Universitatis Comenianae published new progress about 4604-72-2. 4604-72-2 belongs to pyrazines, auxiliary class Pyrazine,Amine,Amide, name is Pyrazine-2-carbothioamide, and the molecular formula is C5H5N3S, Computed Properties of 4604-72-2.
Referemce:
https://en.wikipedia.org/wiki/Pyrazine,
Pyrazine | C4H4N2 – PubChem