Lumma, William C. Jr. published the artcilePiperazinylpyrazines with central serotoninmimetic activity, Application of 2-Chloro-6-(trifluoromethyl)pyrazine, the publication is Journal of Medicinal Chemistry (1978), 21(6), 536-42, database is CAplus and MEDLINE.
Twenty title compounds I [R = H, [CH2)3NMe2, or 6-chloro-2-pyrazinyl; R = H or Cl; R2 = H, Cl, Ph, or CO2Me; R3 = H, Cl, Me, SPh, etc.; X = 2H or O] were synthesized by reaction of the appropriate chloropyrazine with piperazine [110-85-0] or an N-substituted piperazine. I; (R = R1 = R2 = H; R3 = Cl; X = 2H,.HCl) [61655-58-1] had pharmacol. properties in mice characteristic of potent central serotoninmimetic activity and only weak peripheral serotoninmimetic action in isolated rat uterus. Preferred conformations of this compound, determined by classical strain energy calculations and CNDO mol. orbital techniques, were compared with serotonin [50-67-9] in order to determination those structural features which might interact with serotonin receptors.
Journal of Medicinal Chemistry published new progress about 61655-69-4. 61655-69-4 belongs to pyrazines, auxiliary class Trifluoromethyl,Pyrazine,Fluoride,Chloride, name is 2-Chloro-6-(trifluoromethyl)pyrazine, and the molecular formula is C5H2ClF3N2, Application of 2-Chloro-6-(trifluoromethyl)pyrazine.
Referemce:
https://en.wikipedia.org/wiki/Pyrazine,
Pyrazine | C4H4N2 – PubChem