Krinkova, Jana published the artcileIn vitro antifungal activity of 5-alkyl-6-chloropyrazine-2-carboxamides and the corresponding thioamides, Product Details of C5H5N3S, the publication is Folia Pharmaceutica Universitatis Carolinae (2001), 21-26, database is CAplus.
Homolytic alkylation of 6-chloropyrazine-2-carbonitrile by alkanoic acids and subsequent partial hydrolysis afforded 5-alkyl-6-chloropyrazine-2-carboxamides, which were converted by Lawesson’s reagent into corresponding thioamides. Products were tested for their in vitro antifungal activity. The structure-activity relationships were studied. Three of the tested compounds, 6-chloro-5-butylpyrazine-2-carbothioamide, 6-chloro-5-isobutylpyrazine-2-carbothioamide, and 6-chloro-5-(1,1-dimethylethyl)-pyrazine-2-carbothioamide, were active in vitro against all 8 strains tested (MIC values ranged from 62.5 to 500 μmol.dm-3). Thioamides exerted higher antifungal activity than the corresponding amides. The values of hydrophobicity in the series of studied compounds were determined The activity dropped or disappeared at the compounds with lower lipophilicity (log P > 2.28). Some interesting correlation between antimycobacterial and antifungal activity was found.
Folia Pharmaceutica Universitatis Carolinae published new progress about 4604-72-2. 4604-72-2 belongs to pyrazines, auxiliary class Pyrazine,Amine,Amide, name is Pyrazine-2-carbothioamide, and the molecular formula is C5H5N3S, Product Details of C5H5N3S.
Referemce:
https://en.wikipedia.org/wiki/Pyrazine,
Pyrazine | C4H4N2 – PubChem