Hearn, Brian R.’s team published research in Organic Letters in 8 | CAS: 4604-72-2

Organic Letters published new progress about 4604-72-2. 4604-72-2 belongs to pyrazines, auxiliary class Pyrazine,Amine,Amide, name is Pyrazine-2-carbothioamide, and the molecular formula is C5H5N3S, Application In Synthesis of 4604-72-2.

Hearn, Brian R. published the artcileC-15 Thiazol-4-yl Analogues of (E)-9,10-Didehydroepothilone D: Synthesis and Cytotoxicity, Application In Synthesis of 4604-72-2, the publication is Organic Letters (2006), 8(14), 3057-3059, database is CAplus and MEDLINE.

The syntheses and biol. evaluation of six epothilone D analogs are reported. These side-chain variants of the (E)-9,10-didehydroepothilone scaffold contain C15 thiazole appendages that are derived from bromomethyl ketone intermediates. Although each of these analogs is less cytotoxic than the parent (E)-9,10-didehydroepothilone D, three maintain IC50 values in the double-digit nanomolar range against both susceptible and resistant cell lines.

Organic Letters published new progress about 4604-72-2. 4604-72-2 belongs to pyrazines, auxiliary class Pyrazine,Amine,Amide, name is Pyrazine-2-carbothioamide, and the molecular formula is C5H5N3S, Application In Synthesis of 4604-72-2.

Referemce:
https://en.wikipedia.org/wiki/Pyrazine,
Pyrazine | C4H4N2 – PubChem