Garamvolgyi, Rita published the artcileDesign and synthesis of new imidazo[1,2-a]pyridine and imidazo[1,2-a]pyrazine derivatives with antiproliferative activity against melanoma cells, Application In Synthesis of 117718-92-0, the publication is European Journal of Medicinal Chemistry (2016), 623-643, database is CAplus and MEDLINE.
A new series of diarylamide and diarylurea derivatives containing imidazo[1,2-a]pyridine or imidazo[1,2-a]pyrazine scaffold I (R = H, 3,5-F, 3-CF3, etc.), II, III was designed and synthesized to investigate their in vitro efficacy against the A375P human melanoma cell line. Several compounds expressing submicromolar IC50 values against the A375P cells was observed, from which I (R = 3,5-F), II (R = 3,5-Cl), III (R = 3,5-Cl, 3,5-(CF3)2, 4-F-3-CF3) demonstrated the highest potencies with IC50 below 0.06 μM.
European Journal of Medicinal Chemistry published new progress about 117718-92-0. 117718-92-0 belongs to pyrazines, auxiliary class Other Aromatic Heterocyclic,Bromide,Amine, name is 3-Bromoimidazo[1,2-a]pyrazin-8-amine, and the molecular formula is C6H5BrN4, Application In Synthesis of 117718-92-0.
Referemce:
https://en.wikipedia.org/wiki/Pyrazine,
Pyrazine | C4H4N2 – PubChem