Foks, Henryk published the artcilePyrazine derivatives. XIV. Synthesis and tuberculostatic activity of pyrazine amidrazones, Name: Pyrazine-2-carbothioamide, the publication is Acta Poloniae Pharmaceutica (1979), 36(2), 155-60, database is CAplus and MEDLINE.
Cyanopyrazine (I) treated at room temperature with Me2NNH2 gave II (R = H, R1 = NMe2). II (R = H, R1 = NHPh, 1-piperidinyl, and 4-morpholinyl; R = 1-piperidinyl and 4-morpholinyl, R1 = NMe2) were prepared analogously. I heated with Me2NNH2 in MeOH yielded Me pyrazinecarboximidate, which was subsequently hydrolyzed to carbomethoxypyrazine and converted with H2S into pyrazinethiocarboxamide. 2-Chloro-6-cyanopyridazine (III) with H2NNH2 yielded II (R = NHNH2, R1 = NH2); under similar conditions, III and Me2NNH2 yielded IV (R = NHNMe2), which on prolonged heating in MeOH was converted into II (R = NHNMe2, R1 = NMe2). III and PhNHNH2 gave II (R = Cl, R1 = NHPh). With N-aminomorpholine, III gave only IV (R = 4-morpholinyl), whereas with N-aminopiperidine the analogous product was accompanied by some IV (R = 1-piperidinylamino). Weak tuberculostatic activity was noted for all the compounds prepared
Acta Poloniae Pharmaceutica published new progress about 4604-72-2. 4604-72-2 belongs to pyrazines, auxiliary class Pyrazine,Amine,Amide, name is Pyrazine-2-carbothioamide, and the molecular formula is C5H5N3S, Name: Pyrazine-2-carbothioamide.
Referemce:
https://en.wikipedia.org/wiki/Pyrazine,
Pyrazine | C4H4N2 – PubChem